Vessels - atherosclerosis

Question 1

What type of vessels and what part of vessels are affected in atherosclerosis?

Answer 1

medium and large vessels

intima is thickened

Question 2

Describe the appearance pathologically of atherosclerosis?

Answer 2

necrotic lipid core with a fibromuscular cap

Question 3

What causes the fatty streak seen in atherosclerosis?

Answer 3

macros engulf oxidized LDLs

Question 4

What are some complications of atherosclerosis? (5)

Answer 4

1. stenosis of vessels - angina, peripheral disease
2. plaque rupture with thrombosis - MI, stroke
3. plaque rupture with embolization
4. weakening of vessel wall - aneurysm
5. mural thrombosis

Question 5

What microscopically distinguishes embolic atherosclerotic plaques?

Answer 5

cholesterol clefts

Question 6

What are the two types of arteriosclerosis and define each

Answer 6

1. hyaline - proteins leak into vessel wall - pink

2. hyperplastic - hyperplasia of SM - onion skin

Question 7

What type of arteriosclerosis is caused by benign HTN?

Answer 7

hyaline

Question 8

Malignant htn results in what type of arteriolosclerosis?

Answer 8

hyperplastic

Question 9

What is monckeberg medial calcific sclerosis and what does it typically affect?

Answer 9

calcification of media of large arteries
non obstructive - not significant
upper and lower extremities