Vesiular/ bullous Dz

Question 1

What is the underlying etiology of vesicular and bulbous skin dz

Answer 1

Autoimmune blistering diseases

Impaired adhesion of the epidermis to the epidermal basement membrane

Autoantibodies target structural proteins that promote cell matrix or cell-to-cell adhesion in skin

Characterized by substantial morbidity & mortality

Question 2

Pemphigus Vulgaris has near universal involvement of what structures

Answer 2

Deep painful erosions of nearly the entire oral mucosa

Question 3

What is Nikolsky sign

Answer 3

Easily ruptures lesions

Seen in pemphigus vulgaris

Question 4

A blistering D/o assoc with myasthenia gravis
Effects desmoglien in the adhesion of keratinocytes

Positive nikolsky sign

Universal involvement of the oral mucosa

Answer 4

Pemphigus Vulgaris

Refer to Derm

Systemic Steroids and immunosuppressants

Question 5

Mc to elderly, generalize bulbous eruptions, that begin as localized erythema and itchy plaques that becasue dark red/ cyanotic and eventually bullae

Negative Nikolsky sign

Answer 5

Bulbous Pemphigoid

Ref to derm if severe and treat with oral steroids and immunosuppressants

If mild group I topical steroid

Question 6

How do you Dx Bullous Disorders

Answer 6

Bx!

Pemphigus, bollous, and herpetiformis

Question 7

Chronic burning bullae assoc with celiacs dz

On extensor surfaces

Itchy “bug bites” become intense burning papules/ vesicles in groups

Answer 7

Dermatitis Herpitiformis

Tx with gluten free diet and dapsone