GU BLOCK II Flashcards
What is the criteria for a benign cyst on US
Echo free (anechoic)
Sharply demarcated mass w/ smooth walls
Enhanced back wall → indicating good transmission through the cyst
What is the criteria for a benign cyst on CT
Smooth thin wall that is sharply demarcated
No enhancement w/ contrast media
If lesion is inconsistent w/ a simple cyst on CT what is the next step
Surgical exploration
What is the standard of care for a benign cyst
CT non con
And periodic evaluation
What is the most common inherited kidney Dz
Polycystic Kidney Dz
What is the presentation for a patient with PKD
Age 20-40
Abdominal or Flank Pain
Hematuria
(Microscopic or Gross)
Mild-Moderate Proteinuria
Family History (75%)!!! Hypertension (50%)!!!
Low urinary pH
Recurrent UTI or Nephrolithiasis
How do you Dx PKD
Ultrasound
Diagnostic in patient with positive family history and renomegaly in the 3rd or 4th decade of life.
Negative US is less accurate in ruling out disease in patients younger than 30 years so CT or MRI is recommended!!!
What is the treatment for pain in PKD
Bed rest, analgesics (non-NSAID), cyst decompression, avoid long-term use of analgesics, tricyclic antidepressants for chronic pain.
What is the Tx for hematuria in PKD
bed rest & hydration
If persistent → consider renal cell carcinoma (esp., men >50yo)
If a pt has persistent hematuria with PKD think
If persistent → consider renal cell carcinoma (esp., men >50yo)
What is the treatment for renal infection in PKD
Antibiotics that will penetrate cystic wall
(may require up to 2 weeks of IV antibiotics)
What is the treatment for nephrolithiasis
Hydration and pain control
What pregnancy problem is increased in a pt with PKD
ectopic pregnancy
A pt presents with abdominal flank and back pain
Hematuria
HTN
And has cerebral aneurysms
Think
PKD
A pt presents with Swiss cheese appearance of the kidney
Think
Medullary cyst
MEDULLARY SPONGE DZ
How does medullary sponge kidney present
Hematuria
(gross or microscopic)
Recurrent UTIs
Nephrolithiasis
UA may show High urine PH and HyperCa2+
What do you need to Dx Medullary Sponge Kidney
CT scan: shows cystic dilatation of DCT, a striated appearance in this area, & calcifications in renal collecting system.
How does Medullary sponge Kidney Show on IVP
Bouquet of flowers/ paintbrush appearance
What is the Tx for sponge Kidney
Treatment directed toward complications:
-Pyelonephritis/UTI
- Renal calculi → ↑ fluids (2 L/day) to prevent stone formation
- If hypercalciuria → thiazide diuretics to ↓ calcium excretion
- If renal tubular acidosis → alkali therapy
What is the population that gets acquired renal cystic Dz
Largely confined to the ESRD population on dialysis.
What is the most signifigant complication of Aquired Renal cystic Dz
Most significant complication is the malignant conversion of cysts into renal cell carcinoma.
What is the Dx for Acquired Renal Cystic Dz
Made by ultrasonography or CT demonstrating multiple and bilateral renal cysts in patients with CKD or ESRD, and there is NO family history PKD.
Renal CT or MRI is preferable to assess for malignant conversion.
CT with or without Con
What is nephronophthisis
Is characterized pathologically by renal interstitial fibrosis, tubular atrophy with basement membrane thickening and disruption.
Kidney size is generally normal or reduced.
Typically a PEDIATRIC problem!
An infant presents with polyuria, pallor, growth failure and lethagy
Think what kidney problem
Nephronophthisis
What is the definitive Dx for Medullary Cystic Kidney Dz
Mutational analysis is required for definitive diagnosis.
THe majority of urothelial cancers are…
urothelial cell carcinomas.
What is the only know sig RSK fx for renal cell carcinoma
Cigarette smoking is the only known significant environmental risk factor.
What is the triad of renal cell carcinoma
Flank pain, hematuria, and palpable mass
What is the most valuable imaging test for renal cell carcinoma
CT or MRI w/ and w/o con
A solid renal mass is a…..
Solid renal masses are renal cell carcinoma until proven otherwise.
What is the Tx for renal cell carcinoma
Surgical nephrectomy
What kind of cancer is most often seen in pts with tuberous sclerosis
Angiomyolipomas are rare benign tumors composed of fat, smooth muscle, and blood vessels.
What is the most common metz cancer to the kidney
Lung Cancer
What is the most common primary malignant renal tumor of childhood
Nephroblastoma (Wilm’s Tumor)
What is the most common presenting symptom for a Nephoblastoma
Abdominal MASS!!
HTN, PAIN, PAINLESS HEMATURIA.
What is the tx approach to Nephroblastoma (Wilms Tumor)
The treatment includes surgery and chemotherapy with or without radiotherapy.
What are all the rads that you order for a kid with nephroblasotma
Abd US
CT abdomen, pelvis, chest
Bone scan/ Brain imaging
Eventually Bx
Abd mass in a kid
Think
Wilms tumor
nephroblastoma
What is the most common solid renal tumor found in neonates
Mesoblastic nephroma
Found before 6months of age
What are the manifestations of pain assoc with the GU tract
Distention of a hollow organ
(Obstruction, or retention)
Inflammation of an organ against its capsule
(Prostatitis, or pyleonephro)
Malignancy is usually a late sign of advanced Dz
What is the differences between infection pain and obstruction pain
Infection pain: constant, pt may lie still
Obstruction pain: waxes and wanes, typically tend to move about
Define renal colic
Assessed clinically at costovertebral angle (CVA)
May radiate to umbilicus and/or be referred to the ipsilateral testicle/labia
Where does prostatic pain radiate to
May radiate to lumbosacral spine, inguinal canals, or lower extremities
What are the irritative voiding S/s
Frequency, Nocturia, Urgency, Dysuria
What are the obstructive Voiding S/s
Hesitancy, decreased force/ caliber, intermittency, post void dribbling, double voiding
A pt presents with pneumaturia
cc of bubbles in urine and malodourus
Think
Usually secondary to a fistula between bladder & GI tract
Diverticulitis, Colon cancer, Crohn’s Disease
If an elderly pt presents wtih urethral DC and is bloody
What must you R/o
Urethral Carcinoma
If a pt presents with hematuria while on anti platelet or anti coag meds what must you do
a complete evaluation is warranted consisting of upper tract imaging, cystoscopy, and urine cytology.
What is the test of choice for hematuria
CT urogram
What is the test of choice to eval for bladder cancer
Cystoscopy
What does PP on This mean
DDX for hematuria
Period (menses) Prostate, papillary necrosis Obstructive uropathy Nephritic syndrome Trauma, tumor, tuberculosis, thrombosis (renal vein) Hematologic (blood disorder, sickle cell) Infection/inflammation Stones
AN OLD PERSON W/ A HISTORY OF SMOKING (esp., male) PRESENTING W/ PAINLESS HEMATURIA HAS WHAT UNTIL PROVEN OTHERWISE!!
BLADDER CANCER!
What is the most common cause of UTI
Coliform bacteria (E.Coli)
What study is recommended for pts with UTI
Urine Culture
What is the mechanism that protect the walls of the urinary tract
Protective glycosaminoglycan layer → interferes w/ bacterial adherence to walls of urinary tract
What defines complicated UTI
Obstructive conditions (at any level)
Neurologic diseases affecting lower urinary tract function
Diabetes
Pregnancy
Foreign bodies (stones, catheters, stents)
“Complicated UTI”
What is the most common agent of uncomplicated UTI
E. Coli
Others: Klebsiella, Proteus, Entrobacter
Uncomplicated cystitis in men is rare and implies
Infected Stone
Prostatitis
Chronic Urinary Retention
Pts with acute cystitis typically present with S/s when
Symptoms often appear following sexual intercourse
If a male presents with uncomp cystitis
Get what W/u
Because uncomplicated cystitis is rare in men, elucidation of the underlying problem with appropriate investigations, such as -abdominal ultrasonography
- post-void residual testing
- cystoscopy, is warranted.
If you think a pt has pyelonephro
What should you Oder
Follow up CT
Think this in pts with recurrent infections
Define uncomplicated UTI
Acute cystitis in an otherwise healthy non-pregnant adult woman
Anything else is complicated
What is the tx approach for Umcomp UTI
Short Term ABX
1st line: TMP/ SMX
Nitrofurantoin !!!
Fosfomycin
What is the tx approach for post menopausal women with acute cystitis
Postmenopasual women with recurrent cystitis may benefit from vaginal estrogen cream 0.5g nightly for two weeks, then twice weekly.
When would we use prophylactic agents in Recurrent Cystitis
Women w/ >3 episodes/yr. → candidates for prophylactic antibiotics:
Confirmed by urine culture w/symptoms.
DEFINITLTY REFER!
ABX: TMP/SMX, Nitro, or Cephalexin
Single dose at bed time or at time of intercourse
What is the tx approach for a pt with a postive urine culture with no S/s
Typically, don’t require treatment unless pregnant or undergoing invasive urinary tract procedures.
What is the 1st line tx in a pregnant pt with asymptotic baceriuria
Amoxicillin 500mg PO two to three times daily for 3 to 7 days
Nitrofurantoin 100 mg PO two time daily for 5-7 days
Cephalexin 500 mg two to four times daily for 3 to 7 days
What is the most common agents of acute pyelonephritis
E. coli, Proteus, Klebsiella, Enterobacter, & Pseudomonas
What is a mandatory lab for a pt with pyelonephro
URINE CULUTRE
What is the f/u time line for pts with pyelonephritis
Within 48 hours
What is the tx approach to a pt with uncomplicated pyelonephro
Empiric PO antibiotics, pain control, anti-emetic, close follow up
Typically begin w/ quinolone & adjust based on cultures
Fluoroquinolones:
-Levofloxacin 750mg daily x 5 days
Ciprofloxacin 750mg twice daily x 7 -days
If TMP/SMX is used as 1st line then add on ceftriazxone!
What is the admission criteria for pts with pyelonephro
Severe infection
Obstructions
DM
Renal Failure
Resistant microbes
PREGNANT!
Uncontrolled S/s
(Outpt failure with no improvement in 48hours)
What is the duration of tx for inpt pyleonephro
Inpatient, Intravenous antibiotics are continued for 24 hours after fever resolves, and oral antibiotics are given to complete a 14-day course of therapy.
If a pt with pyleonephro with a fever that persists pup to 72 hours
What should you do
Failure to respond w/in 48 hrs. → order imaging (CT or US) to exclude complicating factors (i.e., abscess or obstruction)
Follow-up urine cultures are mandatory
What is the agent that causes Acute epididymitis most often
STI from Chlamydia or Neisseria G.
What agent is common in older men with acute epididmytis
Men who practice insertive anal intercourse may have acute epididymitis from sexually transmitted and enteric organisms.
Stoped at slide 39 k
What are the common cuases of Acute epididmytis
Chlamydia trachomatis or Neisseria gonorrhoeae.
What the only way to rule out torsion
US