Vesiculobullous Lesions

Question 1

Spread through infected saliva or active perioral lesions, skin above waist

Answer 1

HSV1

Question 2

Spread through genital zones, sexual contact, skin below waist

Answer 2

HSV2

Question 3

Most common site of latency for HSV 1

Answer 3

Trigeminal ganglion

Question 4

Numerous pinhead vesicles, rapidly collapse to form numerous small red lesions

Answer 4

Acute herpetic gingivostomatitis/ primary herpes

Question 5

Self inoculation of finger in primary herpes can cause

Answer 5

Herpetic whitlow

Question 6

Most common site for recurrence for HSV 1

Answer 6

Vermillion border & adjacent skin to lips

Question 7

Multiple small, erythematous papules form clusters of fluid filled vesicles

Answer 7

Recurrent herpes simplex infection

Question 8

Acantholysis, ballooning degeneration, Tzank cells

Answer 8

HSV1

Question 9

Lipschütz bodies

Answer 9

HSV1

Question 10

Varicella Zoster Virus also known as

Answer 10

HHV 3

Question 11

Pruritic vesicular rash which becomes pustules which hardens & scab over

Answer 11

Varicella( chickenpox)

Question 12

Chickenpox oral lesion found on

Answer 12

Palate & buccal mucosa

Question 13

In childhood common complications of varicella

Answer 13

Secondary skin infections, encephalitis, pneumonia

Question 14

In adults common complication of varicella

Answer 14

Pneumonitis, encephalitis

Question 15

Where does varicella establish latency

Answer 15

Dorsal root ganglia

Question 16

Involves distribution of affected sensory nerve

Answer 16

Shingles/ hepes zoster

Question 17

Only one recurrence and prevalence increases with age

Answer 17

Shingles/ herpes zoster

Question 18

Distinctive unilateral painful vesicles along the distribution of sensory nerve

Answer 18

Shingles

Question 19

Neural necrosis, neuralgia

Answer 19

Prodormal herpes zoster

Question 20

15% of herpes zoster progress to chonic

Answer 20

Post herpetic neuralgia

Question 21

Hight chances of postherpetic neuralgia if

Answer 21

Ophthalmic involvement

Question 22

Shingles complications

Answer 22

Ramsey Hunt syndrome

Question 23

Involvement of ipsilateral facial & auditory nerves, facial paralysis, hearing deficits, vertigo

Answer 23

Ramsey Hunt syndrome

Question 24

Herpangina caused by

Answer 24

Coxsackie A virus

Question 25

Lesions on posterior part of mouth, soft palate, tonsillar pillars, red macules, fragile vesicles rapidly ulcerates

Answer 25

Herpangina

Question 26

Vesicular eruptions on palms of hands, soles of feet, mucosa of ant of mouth

Answer 26

Hand foot mouth disease

Question 27

Autoimmune mucocutaneous disease- intraepithelial blister formation

Answer 27

Pemphigus Vulgaris

Question 28

Breakdown or loss of intercellular adhesion, acantholysis

Answer 28

Pemphigus Vulgaris

Question 29

Abnormal production of antibodies directed towards desmosomes

Answer 29

Pemphigus Vulgaris

Question 30

Large superficial fragile blister that burst easily

Answer 30

Pemphigus Vulgaris

Question 31

Positive Nikolsky sign

Answer 31

Pemphigus Vulgaris Erythema Multiforme Can be in Mucous Membrane Pemphigoid

Question 32

Suprabasilar vesicles, intra epithelially, row of tombstones, acantholysis, tzank cells

Answer 32

Pemphigus Vulgaris

Question 33

Diagnostic tests for Pemphigus Vulgaris

Answer 33

Biopsy + Direct Immunoflurescence testing

Question 34

Chicken wire or fish net appearance

Answer 34

Pemphigus Vulgaris

Question 35

Chronic blistering oral and ocular mucous membranes

Answer 35

Mucous membrane pemphigoid

Question 36

Antibodies attack on hemidesmosomes

Answer 36

Mucous membrane pemphigoid

Question 37

Desquamative gingivitis

Answer 37

Mucous membrane pemphigoid

Question 38

Most significant complication of Mucous membrane pemphigoid

Answer 38

Ocular involvement-> blindness

Question 39

Subepithelial bullae, no acantholysis, no tzank cells, may be nikolsky sign

Answer 39

Mucous membrane pemphigoid

Question 40

DIF pattern in mucous membrane pemphigoid

Answer 40

Linear pattern

Question 41

Type 3 hypersensitivity reaction

Answer 41

Erythema multiforme

Question 42

Target lesions( iris lesions/ bull’s eye)

Answer 42

Erythema Multiforme minor

Question 43

Hemorrhagic crusting of vermilion zone of lip

Answer 43

Erythema Multiforme

Question 44

Erytherma Multiforme major also known as

Answer 44

Stevens-Johnson syndrome

Question 45

Eye lesions(conjunctivitis), genital lesions(balanitis, vulvovaginitis) , stomatitis

Answer 45

Erythema Multiforme major

Question 46

Erythema Multiforme major triggered by

Answer 46

Sulphonamides