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Oral Pathology > Hematologic Disorders > Flashcards

Hematologic Disorders Flashcards

1
Q

Increase in number of circulating WBC more than 11000/uL

A

Leukocytosis

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2
Q

Reduction in number of WBC less than 4400/uL

A

Leukopenia

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3
Q

Normal differential WBC consists of - Neutrophils

A

50% to 60%

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4
Q

Malignancies that arise from hematopoietic stem cells

A

Leukemia

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5
Q

Malignant transformation of one stem cell which proliferates in bone marrow and overflows into peripheral blood of affected pt

A

Leukemia

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6
Q

Major deficiency of erythrocytes, platelets and leukocytes

A

Leukemia

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7
Q

Less aggressive form of leukemia

A

Chronic Leukemia

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8
Q

Malignancy of myeloid immature WBC

A

Acute myelogenous leukemia

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9
Q

Type of acute leukemia common in adults

A

Acute myelogenous leukemia

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10
Q

Auer rods in myeloblast cytoplasm

A

Acute myelogenous leukemia

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11
Q

Uncontrolled proliferation of immature lymphoid cells in bone marrow

A

Acute lymphocytic leukemia

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12
Q

Type of leukemia most common in children

A

Acute lymphocytic leukemia

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13
Q

Type of leukemia most responsive to therapy

A

Acute lymphocytic leukemia

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14
Q

Malignancy of mature B lymphocytes

A

Chronic lymphocytic leukemia

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15
Q

Least malignant type leukemia, more in adults

A

Chronic lymphocytic leukemia

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16
Q

Neoplasm of mature myeloid WBC

A

Chronic myelogenous leukemia

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17
Q

Philadelphia chromosome

A

Chronic myelogenous leukemi

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18
Q

Chronic myelogenous leukemia progress into

A

Blast phase , more severe

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19
Q

Deficiency of normal cells and invasion of cancerous cells into tissue

A

Leukemia

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20
Q

Diffuse, non tender swelling that may or may not be ulcerated which results in diffuse gingival enlargement

A

Leukemia

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21
Q

Leukocytosis 30,000-100,000 per mm3 with mainly immature form

A

Acute leukemia

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22
Q

Leukemic cells only found in bone marrow and not in blood stream

A

Aleukemic Leukemia

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23
Q

Condition where granulocytic cells neutrophils are absent

A

Agranulocytosis

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24
Q

Trigger to autoimmune reaction which will destroy granulocytes

A

Agranulocytosis

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25
Q

Deep necrotizing punched out ulcers, palate & gingiva

A

Agranulocytosis

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26
Q

Granulocyte colony stimulating factor

A

Filgrastim

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27
Q

Regular periodic reduction in neutrophils

A

Cyclic neutropenia

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28
Q

MCV=

A

Hematocrit/ concentration of RBC

29
Q

Red blood cells paler than usual

A

Hypochromic

30
Q

Red blood cells have increased concentration of hemoglobin

A

Hyperchromic

31
Q

Most common cause of anemia

A

Iron deficiency anemia

32
Q

Angular cheilitis and atrophic glossitis

A

Iron deficiency anemia

33
Q

Hypochromic microcytic red blood cells

A

Thalessemia, iron deficiency anemia

34
Q

Iron deficiency anemia, glossitis, dysphagia, koilonychias, esophageal webs

A

Plummer-Vinson syndrome

35
Q

Pre malignant, increased risk of oral and esophageal squamous cell carcinoma

A

Plummer vinson syndrome

36
Q

Megaloblastic anemia caused by poor intestinal absorption of Vitamin B12

A

Pernicious anemia

37
Q

Decreased ability to absorb vit B12, autoimmune distruction of parietal cells of stomach

A

Pernicious anemia

38
Q

Red blood cells become large and fragile

A

Pernicious anemia

39
Q

Parasthesia, tingling, numbness of extremities

A

Pernicious anemia

40
Q

Atrophic / Hunter glossitis

A

Pernicious anemia

41
Q

Schilling 24 hour urine test

A

Pernicious anemia

42
Q

Hematologic disorder failure of the hematopoietic precursor cells in the bone marrow to produce adequate amount of all types of cells

A

Aplastic anemia

43
Q

Pale oral mucosa, oral ulcerations, gingival hemorrhage , oral mucosal petechiae, purpura, ecchymoses

A

Aplastic anaemia

44
Q

Acellular marrow with extensive fatty infiltration

A

Aplastic anemia

45
Q

Definitive therapy for aplastic anemia

A

Bone marrow transplant

46
Q

Abnormal hemoglobin S , RBC crescent shape(sickle shape)

A

Sickle cell anemia

47
Q

Glutamic acid substituted by valine in B globin chain of hemoglobin

A

Sickle cell anemia

48
Q

Abnormally shaped RBCs clot in vessels and cause recurrent painful episodes-Sickle cell pain crisis

A

Sickle cell anemia

49
Q

Gene Co-dominant

A

Sickle cell anemia

50
Q

Sickle cell trait

A

Sickle cell anemia

51
Q

Bone marrow spaces are enlarged with less trabecular

A

Sickle cell anemia

52
Q

Hair on end appearance on lateral skull radiograph

A

Sickle cell anemia

53
Q

Inherited, abnormal formation of alpha or beta globin chains of hemoglobin

A

Thalassemia

54
Q

Patients with ____ are resistant to malaria

A

Thalassemia

55
Q

More common in Mediterranean population

A

Thalassemia

56
Q

Massive bone marrow hyperplasia, hepatosplenomegaly, lymphadenopathy

A

Thalassemia

57
Q

Painless enlargement of maxilla & mandible, chipmunk face, frontal bossing, flaring of max ant teeth

A

Thalassemia

58
Q

Hemolytic anemia of newborn secondary to blood incompatibility between mother and fetus

A

Erythroblastosis Fetalis

59
Q

Rh incompatibility and ABO incompatibility

A

Erythroblastosis fetalis

60
Q

Enamel hypoplasia, hyperbilirubinemia

A

Erythroblastosis fetalis

61
Q

Hematologic condition, too many functioning red blood cells

A

Polycythemia

62
Q

Blood very thick, thrombus formation

A

Polycythemia

63
Q

Peripheral vascular condition that affects extremities due to thrombotic occlusion of vessels. Painful burning sensation, erythema, warmth

A

Polycythemia

64
Q

Tx of Polycythemia

A

Reduction of RBC mass by removal of as much as 500ml of blood every other day until hematocrit 45% achieved

65
Q

Bleeding disorder caused by decrease in the number of circulating platelets

A

Thrombocytopenia

66
Q

Increase in consumption of platelets causes abnormal clot formation

A

Thrombocytopenia

67
Q

Platelets below 100,000/mm3

A

Thrombocytopenia

68
Q

Minor trauma causes leakage of blood into surrounding connective tissue producing red to purple lesions

A

Thrombocytopenia

Oral Pathology (18 decks)

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