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Hematologic Disorders Flashcards

1
Q

Increase in number of circulating WBC more than 11000/uL

A

Leukocytosis

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2
Q

Reduction in number of WBC less than 4400/uL

A

Leukopenia

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3
Q

Normal differential WBC consists of - Neutrophils

A

50% to 60%

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4
Q

Malignancies that arise from hematopoietic stem cells

A

Leukemia

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5
Q

Malignant transformation of one stem cell which proliferates in bone marrow and overflows into peripheral blood of affected pt

A

Leukemia

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6
Q

Major deficiency of erythrocytes, platelets and leukocytes

A

Leukemia

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7
Q

Less aggressive form of leukemia

A

Chronic Leukemia

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8
Q

Malignancy of myeloid immature WBC

A

Acute myelogenous leukemia

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9
Q

Type of acute leukemia common in adults

A

Acute myelogenous leukemia

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10
Q

Auer rods in myeloblast cytoplasm

A

Acute myelogenous leukemia

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11
Q

Uncontrolled proliferation of immature lymphoid cells in bone marrow

A

Acute lymphocytic leukemia

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12
Q

Type of leukemia most common in children

A

Acute lymphocytic leukemia

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13
Q

Type of leukemia most responsive to therapy

A

Acute lymphocytic leukemia

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14
Q

Malignancy of mature B lymphocytes

A

Chronic lymphocytic leukemia

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15
Q

Least malignant type leukemia, more in adults

A

Chronic lymphocytic leukemia

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16
Q

Neoplasm of mature myeloid WBC

A

Chronic myelogenous leukemia

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17
Q

Philadelphia chromosome

A

Chronic myelogenous leukemi

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18
Q

Chronic myelogenous leukemia progress into

A

Blast phase , more severe

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19
Q

Deficiency of normal cells and invasion of cancerous cells into tissue

A

Leukemia

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20
Q

Diffuse, non tender swelling that may or may not be ulcerated which results in diffuse gingival enlargement

A

Leukemia

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21
Q

Leukocytosis 30,000-100,000 per mm3 with mainly immature form

A

Acute leukemia

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22
Q

Leukemic cells only found in bone marrow and not in blood stream

A

Aleukemic Leukemia

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23
Q

Condition where granulocytic cells neutrophils are absent

A

Agranulocytosis

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24
Q

Trigger to autoimmune reaction which will destroy granulocytes

A

Agranulocytosis

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25
Deep necrotizing punched out ulcers, palate & gingiva
Agranulocytosis
26
Granulocyte colony stimulating factor
Filgrastim
27
Regular periodic reduction in neutrophils
Cyclic neutropenia
28
MCV=
Hematocrit/ concentration of RBC
29
Red blood cells paler than usual
Hypochromic
30
Red blood cells have increased concentration of hemoglobin
Hyperchromic
31
Most common cause of anemia
Iron deficiency anemia
32
Angular cheilitis and atrophic glossitis
Iron deficiency anemia
33
Hypochromic microcytic red blood cells
Thalessemia, iron deficiency anemia
34
Iron deficiency anemia, glossitis, dysphagia, koilonychias, esophageal webs
Plummer-Vinson syndrome
35
Pre malignant, increased risk of oral and esophageal squamous cell carcinoma
Plummer vinson syndrome
36
Megaloblastic anemia caused by poor intestinal absorption of Vitamin B12
Pernicious anemia
37
Decreased ability to absorb vit B12, autoimmune distruction of parietal cells of stomach
Pernicious anemia
38
Red blood cells become large and fragile
Pernicious anemia
39
Parasthesia, tingling, numbness of extremities
Pernicious anemia
40
Atrophic / Hunter glossitis
Pernicious anemia
41
Schilling 24 hour urine test
Pernicious anemia
42
Hematologic disorder failure of the hematopoietic precursor cells in the bone marrow to produce adequate amount of all types of cells
Aplastic anemia
43
Pale oral mucosa, oral ulcerations, gingival hemorrhage , oral mucosal petechiae, purpura, ecchymoses
Aplastic anaemia
44
Acellular marrow with extensive fatty infiltration
Aplastic anemia
45
Definitive therapy for aplastic anemia
Bone marrow transplant
46
Abnormal hemoglobin S , RBC crescent shape(sickle shape)
Sickle cell anemia
47
Glutamic acid substituted by valine in B globin chain of hemoglobin
Sickle cell anemia
48
Abnormally shaped RBCs clot in vessels and cause recurrent painful episodes-Sickle cell pain crisis
Sickle cell anemia
49
Gene Co-dominant
Sickle cell anemia
50
Sickle cell trait
Sickle cell anemia
51
Bone marrow spaces are enlarged with less trabecular
Sickle cell anemia
52
Hair on end appearance on lateral skull radiograph
Sickle cell anemia
53
Inherited, abnormal formation of alpha or beta globin chains of hemoglobin
Thalassemia
54
Patients with ____ are resistant to malaria
Thalassemia
55
More common in Mediterranean population
Thalassemia
56
Massive bone marrow hyperplasia, hepatosplenomegaly, lymphadenopathy
Thalassemia
57
Painless enlargement of maxilla & mandible, chipmunk face, frontal bossing, flaring of max ant teeth
Thalassemia
58
Hemolytic anemia of newborn secondary to blood incompatibility between mother and fetus
Erythroblastosis Fetalis
59
Rh incompatibility and ABO incompatibility
Erythroblastosis fetalis
60
Enamel hypoplasia, hyperbilirubinemia
Erythroblastosis fetalis
61
Hematologic condition, too many functioning red blood cells
Polycythemia
62
Blood very thick, thrombus formation
Polycythemia
63
Peripheral vascular condition that affects extremities due to thrombotic occlusion of vessels. Painful burning sensation, erythema, warmth
Polycythemia
64
Tx of Polycythemia
Reduction of RBC mass by removal of as much as 500ml of blood every other day until hematocrit 45% achieved
65
Bleeding disorder caused by decrease in the number of circulating platelets
Thrombocytopenia
66
Increase in consumption of platelets causes abnormal clot formation
Thrombocytopenia
67
Platelets below 100,000/mm3
Thrombocytopenia
68
Minor trauma causes leakage of blood into surrounding connective tissue producing red to purple lesions
Thrombocytopenia

Oral Pathology (18 decks)

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