Vesiculobullous Disease 1 Flashcards
what type of oral illness comes from cell mediated immunity problems
aphthous ulcers, lichen planus, orofacial granulomatosis
what type of oral illness comes from antibody mediated immunity
pemphigus and pemphigoid
what is an epitope
small part of an antigen which the antibody binds to
what happens to the skin in vesiculobullous diseases when the skin splits
fills with inflammatory exudate
forms vesicle/blister
what causes loss of adhesion between desmosomes causing cell layers to be split
desmoglein
what is direct immunofluorescence
manufacture an antibody with fluorescent marker attached to it which will bind to the antibody already attached so when the light is applied it will show where the antibody is found
when is direct immunofluorescence most useful
in antibody mediated tissue disease (immunobullous condition)
what is indirect immunofluorescence
circulating antibody is not yet bound to the tissue and is detected from a plasma sample
when is indirect immunofluorescence used
for monitoring disease activity
name some vesiculobullous conditions
erythema multiforme
pemphigus
pemphigoid
angina bullosa
bullous lichen planus
what is erythema multiforme
spectrum disorder of immunogenic related skin and mucosa ulceration
what causes erythema multiforme
drugs/herpes simplex causing immune problem
what do oral lesions look like in erythema multiforme
large ulcers
what is stevens johnson syndrome
severe multisystem involvement of erythema multiforme involving the skin, conjunctiva, nose, pharynx, mouth and genitals
what is the immunological reaction in erythema multiforme
antigen present to antibody
combine in circulation
large complex gets stuck in capillaries
complement activation
perivascular inflammatory response
blistering or ulceration
