Venous Thrombosis Flashcards
What is venous thrombosis initiated by? Define:
- thrombus
- embolus
- venous thromboembolism (VTE)
- thrombophlebitis
Lecture 9, slide 8
Discuss the pathology of pulmonary embolisms, systemic embolisms and other emboli?
Lecture 9, slide 9
What is the difference between arterial and venous thrombosis?
Lecture 9, slide 10
What is haemostasis? What are the steps of haemostais?
Lecture 9, slide 11
What is blood clotting? What is the aim of blood clotting? What is is mediated by and what is it a target of?
Lecture 9, slide 13
How are fibrin strands formed in blood clotting?
Lecture 9, slide 14
In what ways can thrombin be activated?
Lecture 9, slide 15-16
How is clotting regulated?
Lecture 9, slide 17-18
What is anti thrombin III? What are the consequences of ATIII deficiency in vitro, in vivo and clinically?
Lecture 9, slide 19-22
What is the role of thrombomodulin?
Lecture 9, slide 24
What is activated C protein?
Lecture 9, slide 25
Where does venous thrombosis occur? What is an embolism?
Lecture 9, slide 29-30
What are some risk factors for venous thrombosis?
Lecture 9, slide 32
Discuss the meaning of relative risk numbers.
Lecture 9, slide 36
What are some genes associated with venous thrombosis risk?
Lecture 9, slide 37-38
How does GWAS work?
Lecture 9, slide 39
What effect may cancer have on the coagulation cascade?
Lecture 9, slide 40
Discuss the association between cancer/cancer treatments and VTE.
Lecture 9, slide 42
Suggest explanations for the association between cancer and VTE
Lecture 9, slide 43-44
How may VTE be prevented in cancer patients?
Lecture 9, slide 46
What is the pathogenesis of cardioembolic stroke?
Lecture 9, slide 48
How may venous thrombosis be prevented in patients with atrial fibrillation?
Lecture 9, slide 50
What are some current anticoagulants used for the treatment and prevention of VTE?
Lecture 9, slide 53
What is heparin?
Lecture 9, slide 54
What forms does heparin come in?
Lecture 9, slide 55
Discuss the applications of heparin and its potential problems.
Lecture 9, slide 56
Suggest an alternative to heparin.
Lecture 9, slide 57
What is the function of warfarin?
Lecture 9, slide 59-62
When is warfarin used?
Lecture 9, slide 63
What are some disadvantages of warfarin?
Lecture 9, slide 64
Why do we need alternatives to warfarin? Suggest alternatives to warfarin.
Lecture 9, slide 65-67
What is Virchow’s Triad?
Lecture 9, slide 70 Factors that promote thrombosis: -endothelial injury/vessel wall damage -haemostasis/changes in blood flow -hypercoagulation/changes in blood constituents
What can cause changes in the vessel wall//endothelial injury?
Lecture 9, slide 71
What changes in blood flow can promote thrombosis?
Lecture 9, slide 72
What changes in blood constituents can promote thrombosis?
Lecture 9, slide 73
What is the difference between a red and white thrombus?
Lecture 9, slide 74
What drugs can be used to treat clotting disorders?
Lecture 9, slide 75