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Cell Pathology > Transplantation > Flashcards

Transplantation Flashcards

1
Q

What are the different sources of donor organs? What are:

  • autografts
  • isografts
  • allografts
  • xenografts
A

Lecture 3, slide 3

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2
Q

What is the MHC locus? How polymorphic is it?

A

Lecture 3, slide 5-6

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3
Q

What is the direct pathway of alloantigen presentation? What is the indirect pathway?

A

Lecture 3, slide 7-8

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4
Q

What are minor histocompatibility antigens? Give some examples.

A

Lecture 3, slide 9

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5
Q

How is an appropriate donor identified? What is the law of diminishing returns in the context of donors for transplantation?

A

Lecture 3, slide 10

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6
Q

What are the effector mechanisms in allograft rejection?

A

Lecture 3, slide 11

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7
Q

How is rejection diagnosed?

A

Lecture 3, slide 12

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8
Q

What are the different types of rejection?

A
  • hyperacute rejection
  • acute rejection
  • chronic rejection
  • graft vs host disease
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9
Q

What is hyperacute rejection? What is acute rejection?

A

Lecture 3, slide 13

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10
Q

What is chronic rejection? What is Graft vs Host Disease? (GvHD)

A

Lecture 3, slide 14

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11
Q

What is the underlying pathology of GvHD? When may it be useful? What is systemic sclerosis?

A

Lecture 3, slide 15

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12
Q

Give some examples of immunosuppressants? What are the general side effects of immunosuppressants?

A

Lecture 3, slide 16

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13
Q

Describe potential permanent solutions to allograft rejection.

A

Lecture 3, slide 17

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14
Q

Discuss the induction of transplantation tolerance to allogeneic skin grafts through a course of mAbs.

A

Lecture 3, slide 18

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15
Q

What is normothermic organ perfusion?

A

Lecture 3, slide 19

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16
Q

What advances have been made in xenotransplantation?

A

Lecture 3, slide 21

17
Q

What is blastocyst complementation?

A

Lecture 3, slide 22-23

18
Q

What can interspecies organogenesis be used for?

A

Lecture 3, slide 24-27

Cell Pathology (10 decks)

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