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Cell Pathology > Amyloid and Prions > Flashcards

Amyloid and Prions Flashcards

1
Q

What may increased mortality due to degenerative disease be partly due to?

A

Lecture 6, slide 3-5

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2
Q

What are the features of amyloid formation? What are the causes of amyloid disease and the associated pathological changes?

A

Lecture 6, slide 6

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3
Q

What is amyloid?

A

Lecture 6, slide 7

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4
Q

What are some peripheral amyloid disorders? What protein are in their amyloids? What are their causes and pathology?

A

Lecture 6, slide 8

  • senile systemic
  • type 2 diabetes
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5
Q

What is senile systemic amyloidosis?

A

Lecture 6, slide 9

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6
Q

What is the amyloid histology of type II diabetes?

A

Lecture 6, slide 11

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7
Q

What are some amyloid diseases of the CNS? What proteins are in their amyloids? What is their cause?

A

Lecture 6, slide 12

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8
Q

What are prion diseases? Give some examples.

A

Lecture 6, slide 13

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9
Q

What are some features of prion diseases?

A

Lecture 6, slide 14

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10
Q

What are some signs and symptoms of CJD?

A

Lecture 6, slide 15

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11
Q

What is a prion? What are the features of prions?

A

Lecture 6, slide 16

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12
Q

What is the difference between the structure of PrPc and PrPSc?

A

Lecture 6, slide 17

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13
Q

What does progressive prion disease require?

A

Lecture 6, slide 18

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14
Q

How is CJD diagnosed?

A

Lecture 6, slide 19

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15
Q

What is Alzheimer’s Disease (AD)? What is its pathology?

A

Lecture 6, slide 21

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16
Q

How can AD histology be imaged?

A

Lecture 6, slide 22

17
Q

What is the histopathology of AD?

A

Lecture 6, slide 23

18
Q

How and why does amyloid form?

A

Lecture 6, slide 24

19
Q

What is the structure of AD amyloid? How is it formed?

A

Lecture 6, slide 25

20
Q

How is amyloid involved in the pathophysiology of AD? What is size exclusion chromatography? What has this technique (and SEM) revealed about the amyloidogenic peptide?

A

Lecture 6, slide 26-31

21
Q

How is chronic inflammation involved in AD pathology?How has this been shown?

A

Lecture 6, slide 32-35

22
Q

What are the general approaches to treatment of amyloid disorders? What are the specific treatment approaches for AD treatment?

A

Lecture 6, slide 36-38

23
Q

Give examples of new drug treatments for AD that have been abandoned. Why was research into them abandoned?

A

Lecture 6, slide 39

Cell Pathology (10 decks)

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