Arterial Thrombosis

Question 1

What are some experimental models of atheroscerosis?

Answer 1

Lecture 8, slide 5

Question 2

How can you induce atherosclerosis in mice?

Answer 2

Lecture 8, slide 6

Question 3

What is the phenotype of the ApoE KO mice?

Answer 3

Lecture 8, slide 7, 9

Question 4

What is the difference LDL and VLDL plasma levels in mice compared to humans? Explain this difference.

Answer 4

Lecture 8, slide 8

Question 5

How can atherosclerosis be quantified?

Answer 5

Lecture 8, slide 10

Question 6

What effect does knocking out ApoE and CCR2 have in mice?

Answer 6

Lecture 8, slide 11-12

Question 7

What are lines of Zahn?

Answer 7

Lecture 8, slide 16

Question 8

What are T cells doing in atherosclerosis?

Answer 8

Lecture 8, slide 21

Question 9

How are platelets involved in haemostasis?

Answer 9

Lecture 8, slide 22

Question 10

How is platelet adhesion mediated?

Answer 10

Lecture 8, slide 23-24

Question 11

What type of storage granules do platelets contain? How is platelet granule release mediated?

Answer 11

Lecture 8, slide 25

Question 12

How is platelet aggregation mediated?

Answer 12

Lecture 8, slide 26

Question 13

How can platelet aggregation be measured.

Answer 13

Lecture 8, slide 27

Question 14

What causes platelet aggregation and what prevents it?

Answer 14

Lecture 8, slide 28

Question 15

How can platelet activation and aggregation be targeted?

Answer 15

Lecture 8, slide 29

Question 16

What are some of the functions of platelets?

Answer 16

Lecture 8, slide 30-31

Question 17

What are the different treatments of arterial thrombosis?

Answer 17

Lecture 8, slide 36

Question 18

What is streptokinase? What is its function, how is it given, when is it used and what are some issues with its use? What does contraindications mean?

Answer 18

Lecture 8, slide 37

Question 19

What is recombinant tPA? What is its function, how is it given, when is it used and what are some issues with its use?

Answer 19

Lecture 8, slide 38

Question 20

What is aspirin? What is its function?

Answer 20

Lecture 8, slide 39

Question 21

What are the different applications of aspirin use. What are some potential problems associated with its use?

Answer 21

Lecture 8, slide 40

Question 22

What is the role of clopidogrel? What is its benefit over aspirin? Give a con of this treatment.

Answer 22

Lecture 8, slide 41

Question 23

What is abciximab? What have clinical studies revealed about its effectiveness?

Answer 23

Lecture 8, slide 42

Question 24

Who is primary prevention given to and what does it focus on? Who is secondary prevention given to and what does it focus on?

Answer 24

Lecture 8, slide 45

Question 25

What is coronary angioplasty?

Answer 25

Lecture 8, slide 47-49

Question 26

What is coronary artery bypass grafting and when may it be used?

Answer 26

Lecture 8, slide 52

Question 27

Give examples of cholesterol lowering strategies.

Answer 27

Lecture 8, slide 54-55

Question 28

What is the function of statins? Give pros and cons

Answer 28

Lecture 8, slide 57

Question 29

What is the general structure of a randomised control trial?

Answer 29

Lecture 8, slide 58

Question 30

What does the Scandinavian Simvastatin Survival Study reveal about the effectiveness of simvastatin?

Answer 30

Lecture 8, slide 59-62

Question 31

What are some of the effects of statins?

Answer 31

Lecture 8, slide 63