Venous Thrombosis Flashcards
Treatment for arterial thrombosis
Aspirin and other anti-platelets
Arterial and venous thrombosis - which one is platelet rich and which one is fibrin rich?
Arterial = platelet rich Venous = fibrin rich
(in the arterial system, high pressure damages the vessel walls and this allows platelet adhesion. In the venous system, the coagulation cascade is activated which is why you get +++fibrin)
List possible causes of increased TF, vWF and factor VIII
- age
- pregnancy
- oestrogen therapy
- malignancy
- trauma/surgery
- infection
What is factor V leiden
Factor V leiden is a mutated form of factor V. Unlike factor V, factor V leiden is not inactivated by proteins C and S so clotting happens
If someone has hereditary thrombophilia, when would you consider long term anticoagulation?
If they have RECURRENT thrombotic events
- short term prophylaxis is to prevent events during periods of known risk
- short term anticoagulation is to treat thrombotic events
Is clinical history or the results of thrombophilia screening more important when deciding the risk of recurrent thrombosis?
Clinical history MUCH more important than results of thrombophilia screen
(i.e. have they ever had a clot before/have they had a clot without any risk factors present e.g. surgery/pregnancy i.e out of the blue)
Which is a greater risk factor for clots - hereditary thrombophilia or (acquired) antiphospholipid antibody syndrome?
Antiphospholipid antibody syndrome is a MUCH greater risk factor for clots than hereditary thrombophilias
Features of antiphospholipid antibody syndrome?
- Recurrent thromboses (arterial, including TIAs, venous)
- Recurrent fetal loss
- Mild thrombocytopenia
Another name for lupus anticoagulants?
Antiphospholipid antibodies
Treatment of anti-phospholipid antibody syndrome and why?
Treatment = aspirin and warfarin
anti-platelet and anti-coagulant because there is activation of both primary and secondary haemostasis
