Haemopoiesis Flashcards
Immediate red cell precursor
Reticulocytes
i think this is why you can get polychromasia
What are myelocytes?
Nucleated precursors between neutrophils and blasts
What is a blast?
A nucleated precursor cell
Which embryo layer are haemopoietic stem cells derived from?
Derived from the MESODERM
The yolk sac is the first site of erythroid activity, when does its activity stop?
By week 10
When does the liver begin to make blood cells?
When does the spleen begin?
By week 6
Spleen works by week 12
When does the bone marrow begin to make blood cells?
By week 16
What is the lining called that separates the bone from the bone marrow?
The endosteum (covered by osteoblasts and osteoclasts)
There is a particularly rich supply of arterioles, as well as sinusoids near the endostium
Difference between red and yellow marrow
Increase in yellow marrow with age - there is a reduction in cellularity in older individuals
When might the myeloid:erythroid ratio reverse?
e.g. in haemolysis as a compensatory response
Where does erythroid maturation occur
Occurs around ‘nurse’ macrophages in the form of islands
What regulates neutrophil maturation?
Regulated by G-CSF (granulocyte-colony stimulating factor)
How can you get some precursor cells?
Bone marrow aspirate
What is immunophenotyping?
This is when you look at the antigens on the cell surface (technique involves using specific antibodies)
What does it mean if there is no fluorescence when you are doing phenotyping?
It means the target molecule you are looking for is not there (it is absent, hence no fluorescence)
