Bleeding disorders Flashcards
1
Q
Where are coagulation factors synthesised?
A
In hepatocytes
2
Q
Which coagulation factors are carboxylased by vitamin K?
A
II, VII, IX and X
3
Q
Where is vitamin K absorbed and what is required for absorption?
A
- absorbed in the upper intestine
- bile salts required for absorption
4
Q
Haemorrhagic disease of the newborn could cause which deficiency?
A
Vitamin K deficiency
5
Q
Name a fibrin degeneration product
A
D-dimers
6
Q
Causes of DIC
A
- sepsis
- malignancy
- hypovolaemic shock
- obstetric emergencies
7
Q
Treatment of DIC
A
- treat underlying cause
- platelet transfusions
- plasma transfusions
- fibrinogen replacement
8
Q
Which is more common, Haemophilia A (factor VIII) deficiency, or Haemophilia B (factor IX deficiency)?
A
Haemophilia A (factor VIII) deficiency
-5x as common as the other one
9
Q
Haemophilia inheritence
A
X-linked
10
Q
Bleeding from which size of vessels in haemophilia?
A
Medium to large blood vessels
