Blood cell tutorial Flashcards
Where do granulocytes do most of their work? i.e. tissues or bloodstream
Tissues
How many days does it take for division and maturation of eosinophils/basophils/neutrophils?
6-8 days
Which type of cell is able to stick to the blood vessel wall (marginate) ?
Neutrophils
How long do neutrophils spend in the blood stream?
Neutrophils are short lived, they spend 6-10 hours in the blood stream, before spending a few days in the tissue and dying
Which of the following can cause eosinophila? :
- malaria
- asthma
- sepsis
- severe eczema
- helminthic infection
- asthma
- severe eczema
- helminthic infection
Which of the following can cause neutrophilia? :
- neoplasia (e.g. carcinoma)
- inflammation
- bacterial infection (especially pyogenic bacteria)
- acute haemorrhage
- tissue necrosis
All of them
Where would you find basophils?
Do not usually circulate in blood, would find them in connective tissues
When might you see basophils?
- asthma
- polycythaemia rubra vera
- chronic myleoid leukaemia
What could cause an increase in the number of eosinophils?
- allergic reactions to drugs
- severe skin conditions (e.g. atopic dermatitis)
- Asthma, atopy
- Parasitic infections
- Hodgkins lymphoma, T cel lymphomas
- PULMONARY SYNDROMES (e.g. eosinophilic pneumonia, Churg Strauss)
The nucleus of this cell is often obscured by blue/black granules
Basophil
What do basophil granules contain?
- heparin
- histamine
What type of receptor would you find on the surface of basophils?
-IgE receptors (these allow specific antibody/antigen interactions to cause degranulation - type 1 hypersensitivity)
Which of the following would cause increased levels of mast cells? :
- systemic mastocytosis
- immune complex disease
- a recent anaphylactic reaction
- severe sepsis
Answer:
- systemic mastocytosis
- recent anaphylactic reaction
What can be measured to look for mast cell degranulation/excessive mast cell numbers
(mast cell) tryptase !!
Malignant proliferation of mast cells causes what?
Systemic mastocytosis
