Haemostasis

Question 1

What is primary haemostasis

Answer 1

Formation of the platelet plug

Question 2

What is secondary haemostasis

Answer 2

Formation of the fibrin clot

Question 3

How are platelets formed- which cell do they bud from?

Answer 3

Platelets are formed in the bone marrow by budding from megakaryocytes

Question 4

Lifespan of platelets?

Answer 4

7-10 days

Question 5

What does the endothelium release when it becomes damages?

Answer 5

Von willebrand factor and other proteins

-platelets have receptors =adhesion at the site of injury

Question 6

Platelets bind to the site of injury and then what?

Answer 6

They release chemicals which then cause aggregation of platelets

Question 7

What activates plasminogen

Answer 7

Tissue plasminogen activator converts plasminogen to plasmin

Question 8

What does plasmin do?

Answer 8

Breaks down fibrin to FDPs (fibrin degeneration products)

Question 9

Screening tests for fibrin clot formation

Answer 9

• prothrombin time

- activated partial thromboplastin time

Question 10

Thrombophilia means patients are more likely to develop ______

Answer 10

Venous thromboembolism!! Pulmonary embolism!!!

Question 11

Name a serine protease inhibitor

Answer 11

Anti-thrombin III (naturally occuring anticoagulant)