Macrocytosis Flashcards
1
Q
What is a megaloblast?
A
An abnormally large nucleated red cell with an immature nucleus
2
Q
Causes of megaloblastic anaemia
A
- B12 deficiency
- Folate deficiency
- Others (drugs, rare inherited abnormalities)
3
Q
Essential co-factors for nuclear maturation
A
B12 and folate
4
Q
Where is vitamin B12 absorbed?
A
Ileum
5
Q
Where is folate absorbed?
A
Duodenum and jejunum
6
Q
Drugs which could cause folate deficiency
A
Anti-convulsants
7
Q
Causes of folate deficiency
A
- Haemolysis
- Exfoliating dermatitis
- Pregnancy
- Malignancy
8
Q
How might patients with pernicious anaemia present and why?
A
Might appear mildly jaundiced due to intramedullary haemolysis
