Pancytopenia Flashcards
1
Q
Red cell lifespan
A
120 days
2
Q
Neutrophil lifespan
A
7-8 hours
3
Q
Platelt lifespan
A
7-10 days
4
Q
Short stature Skin pigment abnormalities Radial ray abnormalities Hypogenitalia Endocrinopathies GI defects Cardiovascular Renal Haematological
A
Fanconi’s anaemia
5
Q
Why does fanconi’s anaemia arise and median age of diagnosis?
A
Arises because DNA damage (unable to correct inter-strand cross links)
Mean age diagnosis = 7
6
Q
Aplastic anaemia arises from the body attacking which type of cell?
A
Haematopoietic stem cell
7
Q
Increased apoptosis of progenitor and mature cells?
A
Myelodysplastic syndrome
8
Q
Causes of splenic congestion
A
Portal hypertension
Congestive cardiac failure
9
Q
Systemic disease that could cause hypersplenism
A
Rheumatoid arthritis
10
Q
Treatment of idiopathic aplastic anaemia
A
Immunosuppression
