Vasopressors and Inotropes

Question 1

Digoxin MOa how does it cause inotropy ?

Answer 1

ct eect of digoxin is via Inhibition of Na+/K+ ATPase is considered to be the primary biochemical mechanism of action. Then
higher intracellular Na reduces action of the Na-Ca pump leading to decreased calcium extrusion and therefore increased intracellular Ca therefore increased inotropy

Question 2

Give MOA and example of phosphodiestrase inhibitor?

Answer 2

Phosphodiesterase inhibitors and Calcium Sensitisers are compounds that cause non-receptor mediated competitive inhibition of phosphodiesterase
isoenzymes (PDE), resulting in increased levels of cAMP

Question 3

Classication of Inotropes and Vasopressors ?

Answer 3

Question 4

MOA catecholamine?

Answer 4