Review Bench-to-bedside review: Rhabdomyolysis – an overview for clinicians

Question 1

Def? crush

Question 2

Pathophysiology ?

Answer 2

Question 3

Etiology ?

Answer 3

Question 4

Mechanisms of ARF in rhabdomyolysis
patients? name 3

Answer 4

Question 5

Diagnosis ?

Clinical manifestations?

Complications early and late?

Lab findings ?

Answer 5

The general manifestations of rhabdomyolysis include malaise,
fever, tachycardia, nausea and vomiting
The classic laboratory
finding is an elevated serum CK of at least five times the normal
value, where the creatinine kinase isoenzyme found predominately
in striated muscle (CK-MM) predominates [109]. Myoglobin
becomes detectable in urine and produces pigmenturia.
Other findings include hyperkalemia, hypocalcemia, hyperphosphatemia
and hyperuricemia along with elevated levels of
other muscle enzymes like lactate dehydrogenase, aldolase,
aminotransferases and carbonic anhydrase III [29

Question 6

Management