HIT

Question 1

Def?

Answer 1

Question 2

Pathogenesis?

Answer 2

Bind PF4
Makes it antigenic
IgG produced binds
Platelet activation

Question 3

How does it present?

When is onset?

Answer 3

mild to severe
Thrombocytopenia
Thrombosis

5-14 days

Question 4

Risk factors ?

Answer 4

Question 5

Diagnosis ?
4 T ?

What is diff diagnosis

What meds ?

Answer 5

Question 6

Special tests?

Answer 6

ELISA

Question 7

Management

Answer 7

Heparin should be discontinued immediately. This applies to
even heparin flushes and heparin-coated catheters.
A non-heparin anticoagulant must be administered even
when the patient does not have thrombosis, as the risk of
new-onset thrombosis is 5–10% per day, even when heparin is
discontinued.1,3,7 The anticoagulant must be continued until the
platelet count has returned to baseline.

Question 7

Management

Answer 7

Heparin should be discontinued immediately. This applies to
even heparin flushes and heparin-coated catheters.
A non-heparin anticoagulant must be administered even
when the patient does not have thrombosis, as the risk of
new-onset thrombosis is 5–10% per day, even when heparin is
discontinued.1,3,7 The anticoagulant must be continued until the
platelet count has returned to baseline.

Question 7

Management

Answer 7

Heparin should be discontinued immediately. This applies to
even heparin flushes and heparin-coated catheters.
A non-heparin anticoagulant must be administered even
when the patient does not have thrombosis, as the risk of
new-onset thrombosis is 5–10% per day, even when heparin is
discontinued.1,3,7 The anticoagulant must be continued until the
platelet count has returned to baseline.