Vasculitis - week 17

Question 1

What is Vasculitis?

Answer 1

inflammation of the blood vessels

Question 2

Types of small vessel vasculitis?

Answer 2

Henoch-Schonlein purpura
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss syndrome)
Microscopic polyangiitis
Granulomatosis with polyangiitis

Question 3

Types of medium vessel vasculitis?

Answer 3

Polyarteritis nodosa
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss syndrome)
Kawasaki Disease

Question 4

types of large vessel vasculitis?

Answer 4

Giant cell arteritis
Takayasu’s arteritis

Question 5

General vasculitis presentation?

Answer 5

Purpura.
Joint and muscle pain
Peripheral neuropathy
Renal impairment
GI disturbance (diarrhoea, abdominal pain and bleeding)
Anterior uveitis and scleritis
Hypertension

systemic features:

Fatigue
Fever
Weight loss
Anorexia (loss of appetite)
Anaemia

Question 6

investigations for vasculitis?

Answer 6

ANCA blood test

also: p-ANCA (MPO antibodies); c-ANCA (PR3 antibodies)

Question 7

Management for vasculitis?

Answer 7

steroids - (prednisolone) vary type of route

Immunosuppressants:

Cyclophosphamide
Methotrexate
Azathioprine
Rituximab and other monoclonal antibodies