Sjogren's Syndrome - week 17

Question 1

What is Sjogren’s syndrome?

Answer 1

Autoimmune condition - Affects the exocrine glands, leads to dry mucous membranes

Question 2

Epidemiology of Sjogren’s syndrome?

Answer 2

Women, 40-50 years

Question 3

Pathophys of Sjogren’s syndrome?

Answer 3

Lymphocytic infiltration and fibrosis of salivary and lacrimal glands

Question 4

Presentation of Sjogren’s syndrome?

Answer 4

Dry eyes (conjunctivitis and blepharitis)
Dry mouth
Small joint pain

Question 5

What is someone with Sjogren’s likely to develop?

Answer 5

Lymphoma

Question 6

Investigation for Sjogren’s syndrome?

Answer 6

Schirmer Test - less 10mm moisture on lower eyelid paper strip
ANA pos
High ESR normal CRP

Question 7

Mangement of Sjogren’s syndrome?

Answer 7

Artificial tears
Artificial saliva
Vaginal lubricants
Hydroxychloroquine to slow progression of disease

Question 8

Complications from Sjogren’s syndrome?

Answer 8

Eye problems (conjunctivitis, corneal ulcers)
Oral problems (dental cavities, candida infections)
Vaginal problems (candidiasis and sexual dysfunction)
Lymphoma

Question 9

Prognosis of Sjogren’s syndrome?

Answer 9

Continual management of flare ups