Granulomatosis with polyangiitis - week 17

Question 1

what is granulomatosis with polyangiitis + epidemiology?

Answer 1

small-vessel vasculitis in nose, sinus, throat, lungs and kidneys
40-65 years of age

Question 2

presentation of granulomatosis with polyangiitis?

Answer 2

epistasis
crusty nasal secretions
hearing loss
saddle nose

cough
wheeze
haemoptysis

glomerulonephritis

Question 3

complications of granulomatosis with polyangiitis?

Answer 3

lung failure
kidney failure
saddle nose
DVT

Question 4

Which antibody is positive for granulomatosis with polyangiitis?

Answer 4

c-ANCA (anti-PR3 antibodies)