Eosinophilic granulomatosis with polyangitis (EPGA - Churg-strauss syndrome) - week 17

Question 1

what is eosinophilic granulomatosis with polyangitis? (EPGA - Churg-strauss syndrome)

Answer 1

small and medium vessel vasculitis that occurs in people with asthma/allergies

Question 2

Presentation of EPGA?

Answer 2

lung and skin problems
presents with severe asthma in late teenage years or adulthood
elevated eosinophil levels

Question 3

Investigation of EPGA?

Answer 3

p-ANCA (anti-MPO antibodies)
ESR/CRP

Question 4

management of EPGA?

Answer 4

cyclophosphamide in conjunction with corticosteroids
rituximab (B-cell depletion)

lowdose glucocorticoids and immunosuppressants such as azathioprine/methotrexate