Vascular, Tumors, Pleura Flashcards
Wedge-shaped infiltrate on CXR is most likely due to what pathology?
Pulmonary embolism/infarct
Mutations in what gene are seen in most cases of pulmonary HTN?
BMPR2
Primary/Idiopathic pulmonary HTN is most common in what population?
20-40 yo women
Autoimmune disease affecting kidneys and lungs due to Abs to collagen IV destroying the basement membranes
Goodpasture syndrome
What is the main population affected by Goodpasture syndrome?
Males 10-20 yo who smoke
What pathology involves the UR/LR tracts and capillaries with granuloma formation and hemoptysis on presentation?
Polyangiitis with Granulomatosis (Wegener Granulomatosis)
What is the average age pt with a lung carcinoma?
40-70 yo
Keratin pearls, intracellular bridges and positive stain for TP53 and P63
SCC
Stain + for synaptophysin, chromogrannin, CD56, MYC
SLCC
Which tumors stain with PAS and Mucicarmine stains?
Adenocarcinoma
Lung cancers in “never smokers” have mutations in which gene and NO mutations in which gene?
Mutation –> EGFR
No Mutation –> KRAS
Which lung cancer has the Azzopardi effect?
SLCC
SIADH and cushing syndrome (ACTH) are associated with which lung cancer?
SLCC
PTH and hypercalcemia are associated with which lung cancer?
SCC
Carcinoid tumors mostly occur in pts of what age?
< 40 yo
Lung carcinoma mostly occurs in pts of what age?
> 50 yo
Which tumor is associated with a chrom 6p21 aberration?
Lung Hamartoma
Which tumor is associated with mutations in TSC2 –> increased mTOR activity
Lymphangioleiomyomatosis
What is the population most affected with Lymphangioleiomyomatosis?
Women of childbearing age
Which tumor is common in children and is associated with ALK gene rearrangements?
Inflammatory Myofiroblastic Tumor
What is characterized by lobulated, yellow-green, creamy puss composed of masses of neutrophils with leukocytes?
Empyema
What are the 3 most common associations with pneumothorax?
Emphysema
Asthma
TB
Which tumor is characterized by soft tissue attached to the pleural surface by a pedicle?
Solitary Fibrous tumor
Solitary Fibrous tumors stain + for ___ and are associated with which fusion gene?
CD34
NAB2-STAT6
Mesothelioma is associated with which chromosome deletion?
Chrom 9, CDKN2A/INK4a
Mesothelioma will stain + for…
Keratin
Calretinin
WT-1
