Vascular, Tumors, Pleura

Question 1

Wedge-shaped infiltrate on CXR is most likely due to what pathology?

Answer 1

Pulmonary embolism/infarct

Question 2

Mutations in what gene are seen in most cases of pulmonary HTN?

Answer 2

BMPR2

Question 3

Primary/Idiopathic pulmonary HTN is most common in what population?

Answer 3

20-40 yo women

Question 4

Autoimmune disease affecting kidneys and lungs due to Abs to collagen IV destroying the basement membranes

Answer 4

Goodpasture syndrome

Question 5

What is the main population affected by Goodpasture syndrome?

Answer 5

Males 10-20 yo who smoke

Question 6

What pathology involves the UR/LR tracts and capillaries with granuloma formation and hemoptysis on presentation?

Answer 6

Polyangiitis with Granulomatosis (Wegener Granulomatosis)

Question 7

What is the average age pt with a lung carcinoma?

Answer 7

40-70 yo

Question 8

Keratin pearls, intracellular bridges and positive stain for TP53 and P63

Answer 8

SCC

Question 9

Stain + for synaptophysin, chromogrannin, CD56, MYC

Answer 9

SLCC

Question 10

Which tumors stain with PAS and Mucicarmine stains?

Answer 10

Adenocarcinoma

Question 11

Lung cancers in “never smokers” have mutations in which gene and NO mutations in which gene?

Answer 11

Mutation –> EGFR

No Mutation –> KRAS

Question 12

Which lung cancer has the Azzopardi effect?

Answer 12

SLCC

Question 13

SIADH and cushing syndrome (ACTH) are associated with which lung cancer?

Answer 13

SLCC

Question 14

PTH and hypercalcemia are associated with which lung cancer?

Answer 14

SCC

Question 15

Carcinoid tumors mostly occur in pts of what age?

Answer 15

< 40 yo

Question 16

Lung carcinoma mostly occurs in pts of what age?

Answer 16

> 50 yo

Question 17

Which tumor is associated with a chrom 6p21 aberration?

Answer 17

Lung Hamartoma

Question 18

Which tumor is associated with mutations in TSC2 –> increased mTOR activity

Answer 18

Lymphangioleiomyomatosis

Question 19

What is the population most affected with Lymphangioleiomyomatosis?

Answer 19

Women of childbearing age

Question 20

Which tumor is common in children and is associated with ALK gene rearrangements?

Answer 20

Inflammatory Myofiroblastic Tumor

Question 21

What is characterized by lobulated, yellow-green, creamy puss composed of masses of neutrophils with leukocytes?

Answer 21

Empyema

Question 22

What are the 3 most common associations with pneumothorax?

Answer 22

Emphysema
Asthma
TB

Question 23

Which tumor is characterized by soft tissue attached to the pleural surface by a pedicle?

Answer 23

Solitary Fibrous tumor

Question 24

Solitary Fibrous tumors stain + for ___ and are associated with which fusion gene?

Answer 24

CD34

NAB2-STAT6

Question 25

Mesothelioma is associated with which chromosome deletion?

Answer 25

Chrom 9, CDKN2A/INK4a

Question 26

Mesothelioma will stain + for…

Answer 26

Keratin
Calretinin
WT-1