Asthma/COPD Pharm

Question 1

What drugs are in the Non-specific ß agonist class?

Answer 1

Epinephrine, Ephedrine, Isoproterenol

Question 2

What drugs are in the ß2 selective class?

Answer 2

Albuterol, Terbutaline, Metaproterenol, Pirbuterol, Levalbuterol

Question 3

When are ß2 selective drugs indicated?

Answer 3

Acute bronchoconstriction and prophylaxis of exercise induces asthma

Question 4

Which ß2 selective drug is given with SubQ injection in emergent situations?

Answer 4

Terbutaline

Question 5

What drugs are in the LABA class?

Answer 5

Salmeterol, Formoterol

Question 6

When are LABA drugs indicated?

Answer 6

To prevent night attacks

Question 7

What drugs are in the ULABA class?

Answer 7

Indacaterol, Olodaterol

Question 8

When are ULABA drugs indicated?

Answer 8

COPD

Question 9

What are the SE’s of ß agonists?

Answer 9

Hypoxemia, cardiac arrhythmias

Tachyphylaxis

Question 10

What are SE’s of the aerosolized versions of ß agonists?

Answer 10

Anxiety, muscle tremors, CV toxicity

Question 11

What drugs are in the Methylxanthine class?

Answer 11

Theophylline, Caffeine

Question 12

What is the MOA of Methylxanthine drugs?

Answer 12

Inhibit PDE –> increased cAMP –> SM relaxation –> bronchodilation

Question 13

How do Methylxanthine drugs help with COPD?

Answer 13

Decrease fatigue on the diaphragm

Question 14

What are the SE’s of Theophylline?

Answer 14

N/V, tremulousness, arrhythmias

Question 15

What drugs does Theophylline interact with?

Answer 15

Erythromycin, Cimetidine, Fluoroquinolones

Question 16

What are the SE’s of Caffeine?

Answer 16

Nervousness, tremor

Question 17

Where is Caffeine commonly prescribed?

Answer 17

NICU

Question 18

What drugs are in the anti-muscarinic class?

Answer 18

Atropine, Ipratropium, Tiotropium, Aclidinium

Question 19

What is special about Ipratropium?

Answer 19

It doesn’t cross into circulation or cross the BBB and it is free of systemic atropine-like SE’s

Question 20

What are Tiotropium and Aclidinium indicated for?

Answer 20

Maintenance therapy of COPD

Question 21

What are the t1/2 of Triotropium and Aclidinium?

Answer 21

Triotropium = 24 hrs
Aclidinium = 12 hrs

Question 22

Which corticosteroid is systemic, given orally, and given in emergencies?

Answer 22

Prednisone

Question 23

What are the SE’s of Prednisone?

Answer 23

Insomnia, behavioral changes, acute peptic ulcers

Question 24

What are the ICS drugs?

Answer 24

Beclomethasone, Budesonide, Ciclesonide, Flunisolide, Fluticasone, Mometasone, Triamcinolone

Question 25

What is the major SE of the ICS drugs?

Answer 25

Oropharyngeal candidiasis

Question 26

Which ICS drugs has the lowest frequency of developing Oropharyngeal candidiasis?

Answer 26

Ciclesonide

Question 27

When are ICS drugs indicated?

Answer 27

Asthma control

Pts with persistent asthma

Question 28

What drugs are in the Leukotriene Pathway Inhibitor class?

Answer 28

Zileuton, Zafirlukast, Montelukast

Question 29

What is the MOA of Zileuton?

Answer 29

Inhibits 5-LIPOX

Question 30

What is the MOA of Zafirlukast and Montelukast?

Answer 30

Inhibits binding of LTD4 to receptor on target tissues

Question 31

Which drugs can be used to reduce the affect of Aspirin-Exacerbated Respiratory Distress?

Answer 31

Zafirlukast

Montelukast

Question 32

Which Leukotriene Pathway Inhibitor can children 12 months old receive?

Answer 32

Montelukast

Question 33

What is the Tx for a pt with mild-intermittent asthma?

Answer 33

SABA prn

Question 34

What is the Tx for a pt with mild-persistent asthma?

Answer 34

SABA prn + ICS daily

SABA prn + Montelukast daily

Question 35

What is the Tx for a pt with intermediate-persistent asthma?

Answer 35

SABA prn + LABA/ICS combo daily

Nebulizer

Question 36

What is the Tx for asthma emergencies?

Answer 36

Prednisone

Epinephrine