RIPE TB Drugs Flashcards
What is the MOA of Isoniazid?
Inhibits synthesis of mycolic acid which is part of cell wall
What are the major SE’s of Isoniazid?
Rash, fever
Hepatitis
Peripheral neuropathy
Anemia, tinnitus, GI pain
What is the MOA of Rifampin?
Binds ß-subunit of bacterial RNA polymerase inhibiting RNA synthesis
How is resistance created to Rifampin?
Point mutations in rpoB which encodes ß-subunit of RNA polymerase
What are the major SE’s of Rifampin?
Orange urine/tears
Jaundice/hepatitis
Fever, chills, myalgia’s
What is the MOA of Ethambutol?
Inhibits arabinoysl transferases which are part of the cell wall
How is resistance created to Ethambutol?
Mutations causing overexpression of arabinoysl
What are the major SE’s of Ethambutol?
Decreased visual acuity
Red-green color blindness
What is the MOA of Pyrazinamide?
Converted to Pyrazinoic acid disrupting cell membrane metabolism and transport functions
How is resistance created to Pyrazinamide?
Impaired uptake of Pyrazinamide
Mutations affecting Pyrazinamid metabolism
What are the major SE’s of Pyrazinamide?
Hepatotoxicity
Hyperuricemia
Photosensitivity
N/V, fever
Which of the RIPE drugs can be used for MAC or Mycobacterium Kansaii?
Ethambutol
What are the 4 different regimens for latent TB infection?
Isoniazid, 9 months
Isoniazid, 6 months
INH + Rifampentine, 3 months
INH + Rifampin, 4 months
Which latent TB Tx is used for pts with HIV?
INH, 9 months
Which latent TB Tx is used for pts without HIV or whom are over 12 yo?
INH + Rifapentine, 3 months
