Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Zak, RSM > Anti-Fungal Pharm > Flashcards

Anti-Fungal Pharm Flashcards

1
Q

What is the MOA of Amphotericin B?

A

Forms complex with ergosterol to destroy fungal membranes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the MOA of Flucytosine?

A

Is converted to 5-dUMP and 5-UTP in the cell which inhibit DNA and RNA synthesis, respectively

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the MOA of the Azoles?

A

Inhibit fungal CYP450 enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the MOA of the Echinocandins?

A

Inhibit Glucan synthase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the suffix of the drugs in the Echinocandin class?

A

-Fungin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How is resistance created against Amphotericin B?

A

Ergosterol alteration in the fungus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How is resistance created against Flucytosine?

A

Altered drug metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How is resistance created against Azoles?

A

Upregulation of fungal CYP450 enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How is resistance created against Echinocandins?

A

Point mutations in Glucan synthase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which Anti-fungal drugs can cross into the CSF?

A

Amphotericin B
Flucytosine
Fluconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which drug is 1st choice for C. Neoformans?

A

Flucytosine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which drug is 1st choice for Cryptococcal meningitis?

A

Fluconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which drug is 1st choice for Aspergillus?

A

Voriconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which drug is used for Aspergillus if pts don’t respond to the other therapies?

A

Caspofungin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which drug is used to Tx dematologic fungal infections?

A

Ketoconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which drug is used for Mucocutaneous candidiasis?

A

Fluconazole

17
Q

What fungi is Amphotericin B used for?

A

Candida, C. Neoformans, Histoplasma, Blastomyces, coccidioides, Aspergillus, Mucormycosis

18
Q

What fungi is Itraconazole used for?

A

Histoplasma, Blastomyces, Sporothrix, Dermatophytes, Onychomycosis

19
Q

What fungi is Posaconazole used for?

A

Mucormycosis, Candida, Aspergillus

20
Q

What is Micafungin used for?

A

Mucocutaneous candidiasis, candidemia

21
Q

What is Anidulfungin used for?

A

Esophageal and invasive candidiasis

22
Q

Which drugs can be used for prophylactic Tx for bone marrow transplants or AIDs pts?

A

Fluconazole

Micafungin

23
Q

Which drug interacts with Rifamycin to decrease the drugs efficacy?

A

Itraconazole

24
Q

Which drug decreases the efficacy of statins, cyclopsorines, and tacrolimus?

A

Voriconazole

25
Q

What are the SE’s of Amphotericin B?

A

Fever, chills, N/V, HA, HoTN, muscle spasms

26
Q

What are the SE’s of Flucytosine?

A

Anemia, leukopenia, thrombocytopenia

27
Q

What are the SE’s of all Azoles?

A

Minor GI issues, abnormal liver enzymes

28
Q

What is the SE specific to Voriconazole?

A

Visual disturbances

29
Q

What is the SE of Anidulafungin?

A

Histamine mediated rash

Zak, RSM (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions