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Zak, RSM > Anti-Fungal Pharm > Flashcards

Anti-Fungal Pharm Flashcards

1
Q

What is the MOA of Amphotericin B?

A

Forms complex with ergosterol to destroy fungal membranes

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2
Q

What is the MOA of Flucytosine?

A

Is converted to 5-dUMP and 5-UTP in the cell which inhibit DNA and RNA synthesis, respectively

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3
Q

What is the MOA of the Azoles?

A

Inhibit fungal CYP450 enzymes

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4
Q

What is the MOA of the Echinocandins?

A

Inhibit Glucan synthase

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5
Q

What is the suffix of the drugs in the Echinocandin class?

A

-Fungin

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6
Q

How is resistance created against Amphotericin B?

A

Ergosterol alteration in the fungus

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7
Q

How is resistance created against Flucytosine?

A

Altered drug metabolism

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8
Q

How is resistance created against Azoles?

A

Upregulation of fungal CYP450 enzymes

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9
Q

How is resistance created against Echinocandins?

A

Point mutations in Glucan synthase

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10
Q

Which Anti-fungal drugs can cross into the CSF?

A

Amphotericin B
Flucytosine
Fluconazole

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11
Q

Which drug is 1st choice for C. Neoformans?

A

Flucytosine

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12
Q

Which drug is 1st choice for Cryptococcal meningitis?

A

Fluconazole

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13
Q

Which drug is 1st choice for Aspergillus?

A

Voriconazole

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14
Q

Which drug is used for Aspergillus if pts don’t respond to the other therapies?

A

Caspofungin

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15
Q

Which drug is used to Tx dematologic fungal infections?

A

Ketoconazole

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16
Q

Which drug is used for Mucocutaneous candidiasis?

A

Fluconazole

17
Q

What fungi is Amphotericin B used for?

A

Candida, C. Neoformans, Histoplasma, Blastomyces, coccidioides, Aspergillus, Mucormycosis

18
Q

What fungi is Itraconazole used for?

A

Histoplasma, Blastomyces, Sporothrix, Dermatophytes, Onychomycosis

19
Q

What fungi is Posaconazole used for?

A

Mucormycosis, Candida, Aspergillus

20
Q

What is Micafungin used for?

A

Mucocutaneous candidiasis, candidemia

21
Q

What is Anidulfungin used for?

A

Esophageal and invasive candidiasis

22
Q

Which drugs can be used for prophylactic Tx for bone marrow transplants or AIDs pts?

A

Fluconazole

Micafungin

23
Q

Which drug interacts with Rifamycin to decrease the drugs efficacy?

A

Itraconazole

24
Q

Which drug decreases the efficacy of statins, cyclopsorines, and tacrolimus?

A

Voriconazole

25
Q

What are the SE’s of Amphotericin B?

A

Fever, chills, N/V, HA, HoTN, muscle spasms

26
Q

What are the SE’s of Flucytosine?

A

Anemia, leukopenia, thrombocytopenia

27
Q

What are the SE’s of all Azoles?

A

Minor GI issues, abnormal liver enzymes

28
Q

What is the SE specific to Voriconazole?

A

Visual disturbances

29
Q

What is the SE of Anidulafungin?

A

Histamine mediated rash

Zak, RSM (14 decks)

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