Ch 15: Morphology

Question 1

Engorged alveolar capillaries an intra-alveolar transudate with presence of hemosiderin-laden macrophages

Answer 1

Pulmonary Edema

Question 2

Heavy lungs exhibiting inflammation, fibrin deposition, and diffuse alveolar damage with hyaline membranes

Answer 2

Acute Lung Injury/Acute Respiratory Distress Syndrome

Question 3

Irreversible enlargement of airspaces with destruction of the bronchiole walls and fibrous deposition

Answer 3

Emphysema

Question 4

Inflammation of airways and hypertrophy of mucus glands causing mucus plug formation and fibrosis

Answer 4

Chronic Bronchitis

Question 5

Airway bronchoconstriction with presence of cuschmann spirals, Charcot-Leyden crystals, and airway remodeling

Answer 5

Asthma

Question 6

B/l lower lobe destruction of SM and elastic tissue by necrotizing infections causing dilation of bronchi and fibrosis

Answer 6

Bronchiectasis

Question 7

Inflammation and fibrosis of pulmonary interstitium

Answer 7

Restrictive/Interstitial lung disease

Question 8

Patchy interstitial fibrosis with honeycomb fibrosis and cobblestone appearance of pleural surfaces

Answer 8

Interstitial Fibrosis (UIP)

Question 9

Carbon-laden macrophages around a network of collagen fibers mostly affecting the upper lobes

Answer 9

Coal Workers’ Pneumoconiosis

Question 10

Nodules in hilar LNs and upper lung zones with whorled appearance and eggshell calcification

Answer 10

Silicosis Pneumoconiosis

Question 11

Diffuse interstitial fibrosis with presence of fusiform/beaded rods with translucent center, Ferruginous bodies, and pleural plaques

Answer 11

Asbestos-Related Pneumoconiosis

Fusiform rods = asbestos bodies

Question 12

Non-necrotiing granulomas with varying stages of fibrosis and hyalinization and presence of Schaumann and Asteroid bodies

Answer 12

Sarcoidosis

Question 13

Large numbers of macrophages with abundant cytoplasm with dusty brown pigment in air spaces

Answer 13

Smokers’ macrophages

Question 14

Intra-alveolar pink granular material, type 2 pneumocyte hyperplasia, interstitial fibrosis, and alveolar simplification

Answer 14

Surfactant Dysfunction Disorder

Question 15

Infarct with areas of ischemic necrosis of alveolar walls, bronchioles, and vessels

Answer 15

Pulmonary Embolism/Infarction

Question 16

Focal necrosis of alveolar walls with intra-alveolar hemorrhages and alveoli containing hemosiderin-laden macrophages

Answer 16

Goodpasture syndrome

Question 17

Bilateral patchy consolidation of the lung gravitating to the lower lobes

Answer 17

Bronchopneumonia

Question 18

Diffuse consolidation of a lobe of the lung

Answer 18

Lobar pneumonia

Question 19

Vocal cord swelling with abundant mucus production with an interstitial inflammatory rxn involving alveolar walls

Answer 19

SARS

Question 20

Suppurative destruction of lung parenchyma within central area of caitation

Answer 20

Lung abscess

Question 21

Granulomas that undergo caseating necrosis and coalesce creating large areas of consolidation

Answer 21

Histoplasmosis

Question 22

Suppurative granulomas with possible miliary infiltrates

Answer 22

Blastomycosis

Question 23

Thick-walled, non-budding spherules filled with small endospores in macrophages

Answer 23

Coccidioidomycosis

Question 24

Collar-button lesions with organoid, trabecular, palisading, ribbon, or rosette-like arrangements of cells

Answer 24

Carcinoid tumors

Question 25

Nodules of CT intersected by epithelial cells

Answer 25

Lung Hamartoma

Question 26

Proliferation of perivascular epithelioid cells that express markers for melanocytes and SM cells

Answer 26

Lymphangioleiomyomatosis

Question 27

Proliferation of spindle-shaped fibroblasts and myofibroblasts, lymphocytes, and plasma cells with peripheral fibrosis

Answer 27

Inflammatory Myofibroblastic tumor

Question 28

Epithelioid type tumor with cells forming tubular/papillary structures resembling adenocarcinoma

Answer 28

Mesothelioma

Question 29

Polypoid plugs of loose organizing CT (Masson bodies) in alveoli

Answer 29

Cryptogenic Organizing Pneumonia (BOOP)