Varicella Zoster and Human Herpes 6 and 7 Flashcards
What are the microbiological properties of Varicella Zoster and HHV 6 and 7
They are linear, ds DNA viruses. They have an icosahedral capsid, they are enveloped
3 classes of herpes virus are?
Alphaherpesviruses, Betaherpesviruses, Gammaherpesviruses
Which class has a neurotrophic latency?
Alpha herpes virus
Which class has a lymphtrophic latency?
Betaherpesvirus
What class does VZV belong to>
Apha…so alpha has a neurotrophic latency
What class do HHV 6 and 7 belong to?
Beta…so they have lymphotrophic latency
During latency…
No virus particles are produced and the entire genome is maintained extra-chromosomally.
What are the 3 stages of latency
Establishment, Maintenance, Reactivation
Primary infection with VZV>
Varicella (chickenpox)
Describe chickenpox
Starts as a fever and progresses to an itchy rash on the scalp and trunk. Most common in late winter and early spring. Spread in an aerosol form. Can be much more serious in adults where it often causes pneumonia
What is zoster
Shingles. often occurs on one dermatome in the thoracic region or on the forehead. Rash usually gone in 2-4 weeks, but the pain can stay much longer.
VZV vaccine is live attenuated
Truth
Pneumonia in adults may require what>
VZV Ig
What is shingles treated with
Acycolvir and steroids
What do HHV 6 and 7 cause
Roseola (exanthum subitum)
