Varicella Zoster and Human Herpes 6 and 7 Flashcards

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1
Q

What are the microbiological properties of Varicella Zoster and HHV 6 and 7

A

They are linear, ds DNA viruses. They have an icosahedral capsid, they are enveloped

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2
Q

3 classes of herpes virus are?

A

Alphaherpesviruses, Betaherpesviruses, Gammaherpesviruses

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3
Q

Which class has a neurotrophic latency?

A

Alpha herpes virus

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4
Q

Which class has a lymphtrophic latency?

A

Betaherpesvirus

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5
Q

What class does VZV belong to>

A

Apha…so alpha has a neurotrophic latency

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6
Q

What class do HHV 6 and 7 belong to?

A

Beta…so they have lymphotrophic latency

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7
Q

During latency…

A

No virus particles are produced and the entire genome is maintained extra-chromosomally.

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8
Q

What are the 3 stages of latency

A

Establishment, Maintenance, Reactivation

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9
Q

Primary infection with VZV>

A

Varicella (chickenpox)

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10
Q

Describe chickenpox

A

Starts as a fever and progresses to an itchy rash on the scalp and trunk. Most common in late winter and early spring. Spread in an aerosol form. Can be much more serious in adults where it often causes pneumonia

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11
Q

What is zoster

A

Shingles. often occurs on one dermatome in the thoracic region or on the forehead. Rash usually gone in 2-4 weeks, but the pain can stay much longer.

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12
Q

VZV vaccine is live attenuated

A

Truth

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13
Q

Pneumonia in adults may require what>

A

VZV Ig

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14
Q

What is shingles treated with

A

Acycolvir and steroids

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15
Q

What do HHV 6 and 7 cause

A

Roseola (exanthum subitum)

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16
Q

What is Roseola

A

Its a mild respiratory illness that is followd by high fever. Fewer than 25% of children present with a rash on their face and body after fever.

17
Q

What age group comes down with Roseola?

A

3 mos- 6 years of age….greater than 90% of US is seropositive.