SKin Intro: What the skin does

Question 1

Predominant role of the epiderimis

Answer 1

Barrier

Question 2

Predominant role of the dermis

Answer 2

Structural and nutritional support

Question 3

What are autoimmune bullous diseases

Answer 3

Disorders of epidermal adhesion or cohesion mediated by autoantibodies to the skin adhesion molecules.
Characterized by large blisters

Question 4

What is the purpose of a desmosome

Answer 4

Connects Keratinocytes to each other

Question 5

What is the purpose of a hemidesmosome>

Answer 5

Connect keratinocytes to the basement membrane

Question 6

Anti-hemidesmosome autoantibodies cause

Answer 6

Bulous pemphigoid….black guy with large skin blisters

Question 7

Anti-desmosome autoantibodies cause

Answer 7

Pemphigus vulgaris

Question 8

Hypohidrotic ectodermal dysplasia

Answer 8

Michael Berryman has this disease. abnormal hair folicles, sweat glands, teeth, fingernails. People that suffer from this disease cannot regulate their body temperature well and are extremely sensitive to heat.

Question 9

Is Hypohydrotic ectodermal dysplasia genetic?

Answer 9

Yes

Question 10

What is the gene mutation in hypohydrotic ectodermal dysplasia

Answer 10

Mutations in the EDAR gene which codes for the ectodysplasin A receptor. This protein is critical for proper interactionb between the developing ectoderm and mesoderm

Question 11

Raynaud’s phenomenon

Answer 11

Chronic episodic attacks of digital ischemia provoked by the cold. It is very painful and may be associated with underlying autoimmune disease

Question 12

Sensory nerve dysfunction may result in?

Answer 12

Itch, dysesthetic pain/burning (feels like acid under the skin), hyperesthesia

Question 13

What is melanin

Answer 13

A dark pigment that helps protect against UV damage