Anti-virals Flashcards
All of the -cyclovirs do what?
Competitively inhibit DNA polymerase, compete with deoxygunosine triphosphatefor entry into viral DNA
Acyclovir used to treat
VZV
Acyclocir
seizures. acyclovir makes you psycho
Famciclovir
VZV and HHV-8 (latent)valacyclovir
AE of famciclovir
Can cuase nephrotoxicity.
Ganciclovir treats
HHV 6 and 8 (active)
AE of Ganciclovir
Teratogenic and myelosuppresive
valacyclovir
pro-drug, treats VZV and HHV-8 Latent
Valgancyclovir
HHV6 and 8 latent. myelosuppresive and t4eratogenic
CIDFOVIR
this is a non-cyclovir and the non-cyclovirs are not reliant on intracellular kinase phosphorylation as a prerequisite for activity so they…ARE ACTIVE AGINST KINASE deficient strains
Pox family and hhv 6,7,8
foscarnet
hhv 6