Vaccines

Question 1

What are the pros of Live, attenuated vaccines?

Answer 1

They retain ability to replicate, promoting humoral and cell-mediated responses. Dont need booster shots.

Question 2

What are the cons of live, attenuated vaccines?

Answer 2

May mutate back to pathogenic form. May have more side effects. May require a cold chain for stability during transport.

Question 3

What are the pros of inactivated vaccines?

Answer 3

No reversion to pathogenic form. Often more stable/easy to store and transport.

Question 4

What are the cons of inactivated vaccines?

Answer 4

Require booster shots. Dont replicate in host so no cell mediated immunity. manufacturing risk.

Question 5

What are subunit vaccines?

Answer 5

Use purified macromolecules derived from pathogen.

Question 6

What are recombinant vector vaccines?

Answer 6

attenuated pathogen genetically egineered to carry another pathogens genes and express them.

Question 7

What are DNA vaccines?

Answer 7

Plasmids carrying pathogen genes injected into muscle tissue where host cells take up and express internally.

Question 8

What is adjuvants?

Answer 8

chemicals that can help enchance the immune response to vaccine.

Question 9

What are the following Adjuvants and what can they help in vaccine immune response? (Alum,MF59,Quil A)

Answer 9

Alum=Stimulates Th2
MF59=oil in water emulsion that slows ag delivery
Quil A= Saponin, aids in antigen penetration.