Adaptive Immunity II Flashcards
What do neutralizing antibodies do?
Bind to viruses, bacteria, and toxins to prevent their attachment to host cells.
What is avidity?
The overall strength of association of a multivalent antibody and a multivalent antigen.
What does affinity deal with?
1 epitope to paratope only.
What is the basic structure of antibodies?
two identical heavy chains and 2 identical light chains.
How many domains do the heavy and light chains of antibodies have? How many variable and constant?
Light=2 domains
Heavy= 4 or 5 domains
Each have 1 variable domain with the rest being constant.
What regions do heavy and light chains contain?
Heavy= V,D,J
Light=V,J
What are the hypervariable regions of the antibody made of what what do they create?
Made up of three CDR loops on each chain creating the unique antigen-binding pocket of the antibody molecule.
which antigen classes are polymers with a J chain?
IgA and IgM
Which antigen classes have an extra C domain?
IgM and IgE
Which antigen classes have subclasses?
IgA and IgG
WHat are the properties of IgM?
Involved in neutralization, complement activation.
What are the properties of IgG?
involved in neutralization, complement activation. Main class in blood and tissue with 4 isotypes. Can cross placenta.
what are the properties of IgA?
Neutralization, protection of mucosa secreted in tears, sweat, saliva, and milk.
IgE properties?
activation of mast cells and basophils. involved in allergies
IgD properties?
Only acts as an antigen receptor on naive follicular B cells.
