Hypersensitivities

Question 1

What are haptens?

Answer 1

Small molecules that covalently bind to proteins, and when processed by APCs, they can activate TH1 cells or TFH cells.

Question 2

Type I hypersensitivities is mediated by what Ig class that does what?

Answer 2

IgE production that sensitizes mast cells.

Question 3

What is Atopy?

Answer 3

The tendency to allergic responses.

Question 4

Type I hypersensitivity also known as? Examples?

Answer 4

Known as allergy HS. Asthma, Hay fever, Food allergies.

Question 5

Type II hypersensitivities is mediated by what Ig class that does what? Known as? Examples?

Answer 5

IgG that recognizes antigen on a cell surface. Known as cytotoxic HS. Autoimmune disease, blood transfusions.

Question 6

Type III hypersensitivity is mediated by what Ig class that does what? Also know as what? Examples?

Answer 6

Driven by IgG that binds soluble antigens to form immune complexes. Also called immune complex HS. Serum sickness and rheumatoid arthritis are examples.

Question 7

Type IV is mediated by what? Known as? Examples?

Answer 7

Is cell mediated by TH1 or Cytotoxic T cells. known as delayed HS. Poisen ivy, TB test, Celiacs, Graft rejection.