Innate Immunity II Flashcards
What are some anitmicrobial peptides?
a-defensins, b-defensins, Cathelicidins
In the small intestine crypts, how are microbes prevented from accumulating?
Paneth cells in the bottom of the crypt produce a-defensins.
How do defensins kill microbes?
By binding to the membranes and generating pores.
How do Collectins and Ficolins function?
recognize and bind to specific carbohydrates on microbial surfaces. Increases phagocytosis or activates compliment.
What is the complement system?
blood proteins that start an enzymatic cascading system of immune defense.
What does the compliment system result in?
Lysis, Chemotaxis, Opsonization, and inflammation.
What are the three complement pathways and what activate them?
- Lectin: MGL, Ficolins
- Classical: IgG, IgM, Pentraxins
- Alternative: Microbial Surfaces.
At which point in the cascade do the 3 complement systems converge?
Cleavage of C3 by C3 convertase.
What complement proteins cause the following: Inflammation/Chemoattraction, ,Phagocytosis, Attack on Membranes, Antibody production
Inflammation/Chemo=C3b, C5a.
Phagocytosis=C3b
Attack on membranes:C5b, C6,7,8,9.
Antibody: C3b
What complex is coupled with the antibody or pentraxin binding in the classical pathway?
C1q/r/s Complex
What couples to MBL in the Lectin pathway?
MASPs
What are Toll Like Receptors?
Receptors that recognize PAMPs and induce signalling.
What do TLR9 and TLR3 do?
Toll like receptors that Transduce signals that result in production of cytokins
