UTI Flashcards
What distinguishes an upper UTI from a lower?
Upper includes the kidneys
Desribe ABU
Asymptomatic bacteremia that does not have sx
Gold standard for dx of UTI
culture
An urine analysis ain’t worth this?
sh*t
What things would one expect to find in a positive UA
bacteria, WBC, inflammatory cytokines
Tx for UTI
TMP-SMX - W alos Nitrofurantoin, M- FLouroquinolone
Causative agents for uncomplicated UTI?
E.coli (75%), S.Saprohyticus (5-15%)
Describe what makes a UTI complicated?
If it is caused by the use of a catheter, genetic abnormalities, obstruction, problems emptying bladder.
What percent of polynephritis is of blood origin?
10%
What virulence factors make E.coli the VIP of UTI’s?
surface adhesions faciliate binding to epithelial cells
P fimbriae - bind renal epithelial cells (polynephritis and bloodstream infections)
Type 1 pili - mediate binding to uroepithelial cells
List risk factors for uncomplicated UTI
intercourse, antibiotic use, diaphragm/spermicide use, recurrent UTI
List causes for complicated UTI.
E.coli, S.Aureus, Entercocci, yeast/fungal, Kliebassa, Pseudomonas
Triangle of pathogenesis for UTI? includes with factors?
Organism, host, enviroment
What are the 5 innate defenses against bacterial UTI
- urine flow
- urine chemistry- lysoyzmes and lactaferrin
- cell surface proteins
- normal flora
- secretory IgA
3 major source of UTI
- community acquired - GI flora
- Nosocomial - caths etc.
- Immune - Glomerulonephritis