Arrythmia drugs

Question 1

Describe a IA Na channel blocker

Answer 1

Increase in ERP and moderate block

Question 2

Name the class IA drugs

Answer 2

Disopyramide, Quinidine, Procanomide

Question 3

Name the 4 beta blockers

Answer 3

Propanolol, Acebutylol, Esmolol, Sotalol

Question 4

Which type of drugs slow the uptake of AP

Answer 4

Class IA and IC

Question 5

Which drugs are oral congeners of Lidocaine

Answer 5

Mexiletine, Tocainide

Question 6

Which Class II drug is a selective beta blocker? For which receptor?

Answer 6

Acelbutylol, Esmolol

Beta1

Question 7

What is the primary use of Procainamide?

Answer 7

Atrial/Ventriular arrythmia

Question 8

Goals of Antiarrhythmic drugs?

Answer 8

Reduce pacemaker activity and modify conduction, refractory time

Question 9

Describe a paroxysmal supraventricular tachycardic rhythm

Answer 9

rapid, regular rhythm that abruptly switches

Question 10

How is an increase in refractory period made possible?

Answer 10

Block K+ Channels

Question 11

What is the key finding in a supraventricular arrythmia?

Answer 11

P wave not seen

Question 12

what is accesory pathway tachycardia?

Answer 12

heart rhythm in which there is a long gap with no activity

Question 13

what is seen in premature venticular contractions?

Answer 13

a couple of really large QRS complexes

Question 14

When do use/state dependant drugs work the best?

Answer 14

bind activated (phase 0) or bind inactivated (phase 2)

Question 15

What are some causes of arrhythimia?

Answer 15

impulse rate, conduction, site of origin

Question 16

Which 2 things are disturbed in an arrythmia?

Answer 16

impulse formation and conduction

Question 17

Two ways in which the HR can be decreased?

Answer 17

change diastolic slope or hyperpolarize

Question 18

In what areas can a block disrupt eletric signals?

Answer 18

SA node, AV node, Bundle of HIS, Bundle branch, Fascicles

Question 19

What is the most common type of afterdepolarization causing arrythimia?

Answer 19

early - with a slow hr

Question 20

things that are necessary for re-entry?

Answer 20

obstacle, uni-direction block, conduction time>refractory period

Question 21

Drugs not to be used with bradycadia

Answer 21

Dofetilide and Diltazem

Question 22

Drugs contrindicated in Wolf Parkinson White

Answer 22

Verapamil and Digitalis

Question 23

Only anti-arrhythmia used to prevent bradycardia

Answer 23

Acebutylol

Question 24

Drugs that can cause tdp

Answer 24

Class IA, Sotalol, Ibutilide

Question 25

Anti-arrhythmia drugs used for SVT?

Answer 25

Esmolol Verapamil, Adenosine

Question 26

Key to remember Propafenone and Propanolol

Answer 26

Propafenone can’t use post MI, Propanolol prevents recurrent MI