Urticaria and Angioedema

Question 1

Edema of the papillary body.

Answer 1

Wheals

Question 2

Edema of subcutaneous tissue and dermis

Answer 2

Angioedema

Question 3

Incidence

Answer 3

15-23% of population

Question 4

How many percent of patients with chronic urticaria of > 6 months duration still have urticaria 10 yrs after.

Answer 4

40%

Question 5

Treatment

Answer 5

H1 blockers- loratadine usually controls most cases of chronic urticaria, but cessation of therapy usually results in recurrence;if they fail, H1 and H2 blockers (cimetidine) and/or mast cell–stabilizing agents (ketotifen). Dox- epin, a tricyclic antidepressant
Prednisone-acute urticaria with angio- edema;also orangioedema–urticaria– eosinophilia syndrome.
Danazol/ orstanozol - Long term tx for HAE
Omalizumab- Chronic idiopathic urticaria thatisnotcontrolledbyantihistamines