Pellagra

Question 1

Is deficient in..

Answer 1

Niacin and tryptophan

Those in maize diet

Question 2

3Ds of Pellagra

Answer 2

dermatitis, diarrhea, and dementia

Question 3

Skin lesions progression

Answer 3

The disorder begins with a symmetric itching and smarting erythema on the dorsa of the hands, neck,and face.
Vesicles and bulla may erupt and break,so that crusting occurs and lesions become scaly.
Later,skin becomes indurated,lichenied,rough,covered by dark scales and crusts; there are cracks and fissures and a sharp demarcation from normal skin

Question 4

Distribution

Answer 4

dorsa of hands and fingers(“gauntlet”)
band-like around the neck(“Casal necklace”) , dorsa of feet up to malleoli with sparing o the heel, and butterfly region of the face.

Question 5

Treatment

Answer 5

100 to 300 mg niacinamide orally plus other B vitamins lead to complete resolution.