Erythema multiforme syndrome

Question 1

Lesion.

Answer 1

erythematous iris-shaped papular and vesiculobullous lesions.

Lesionsmaydevelopover
≥ 10 days. Macule → papule (1 to 2 cm) → vesicles and bullae in the center o the papule. Dullred.Irisortarget-likelesionsresultand are typical

Symmetrical. bilateral

Question 2

Distribution

Answer 2

Extremities and mucosal membrane

Dorsa o the hands, palms, and soles; forearms, feet, face, elbows and knees; penis (50%) and vulva

Question 3

Related to what virus/ infection

Answer 3

HSV

Question 4

Prevention of recurrence.

Answer 4

Anti HSV medication

Question 5

age of onset

Sex.

Answer 5

50% 20 yo

Males

Question 6

Most often occurs as a drug reaction, always with mucous membrane involvement; severe, extensive, tendency to become confluent and bullous, positive Nikolsky sign in erythematous lesions

Answer 6

Severe form (EM MAJOR)

Question 7

Little or no mucous membrane involvement;vesicles but no bullae or systemicsymptoms

Answer 7

Mild (EM minor)

Question 8

Dermatopathology.

Answer 8

Inflammation characterized by perivascular mononuclear infiltrate, edema of the upperdermis; apoptosis of keratinocytes with focal epidermal necrosis and subepidermal bulla ormation

Question 9

Prevention

Answer 9

Control of herpes simplex using oral valaciclovir or amciclovir

Question 10

Tx in severely ill pxs

Answer 10

systemic glucocorticoids are usually given (prednisone, 50 to 80 mg/d in divided
doses, quickly tapered),