Behcet disease

Question 1

It is a perplexing multisystem vasculitic disease with multiorgan involvement.
■ Main symptoms are recurrent oral aphthous ulcers, genital ulcers, erythema nodosum, superficial thrombophlebitis, skin pustules, iridocyclitis, and posterior uveitis
Diagnosis.

Answer 1

Behcet disease

Question 2

Is it a chronic relapsing progressive course?

prognosis:

Answer 2

Yes. Poor prognosis

Question 3

Age predilection.

gender

Answer 3

Male

3/4th decade

Question 4

These are Punched-out ulcers(3to>10mm) with rolled or overhanging borders and necrotic base, red rim in oral mucosa, vulva, penis, scrotum that are really painful.

Answer 4

Aphthous ulcers

Question 5

Dermatopathology.

Answer 5

Leukocytoclastic vasculitis with fibrinoid necrosis of blood vessel walls in acute early lesions;
lymphocytic vasculitis in late lesions.

Question 6

Pathergy test is read after how many hours?

Answer 6

24-48hrs

Question 7

+ in HLA type?

Answer 7

HLA B5, B51

Question 8

Treatment for Aphthous ulcers.

Answer 8

Potent topical steroid 
traimcinolone Intralesional 3-10mg/ml
Thalidomide 50-100mg/day in evening po 
Colchicine 0.6mg 2-3x/day
Dapsone 50-100 mg/ day

Question 9

Systemic tx.

Answer 9

Prednisone with or without azathioprine, cyclophosphamide, azathioprine alone, chlorambucil, and cyclosporine.

Question 10

How many scores to dx Behcet.

Answer 10

3 points