urological cancers

Question 1

cisplatin drug class

Answer 1

alkylating agent

Question 2

which part of the cell cycle does cisplatin work on

Answer 2

non cell cycle specific

Question 3

how do alkylating agents work

Answer 3

1) Attachment of alkyl groups to DNA bases = fragmentation
2) DNA damage via cross-linking prevents DNA
3) nucleotide mispairing = mutations.

Question 4

what is Sunitinib

Answer 4

receptor tyrosine kinase (RTK) inhibitor

Question 5

what is Sunitinib used to treat

Answer 5

renal cell carcinoma

Question 6

Bevacizumab inhibits

Answer 6

VEGF

Question 7

what is Goserelin

Answer 7

luteinizing hormone releasing hormone super agonist

Question 8

what is Cyproterone acetate

Answer 8

anti androgen

Question 9

Cyproterone is used to treat

Answer 9

palliative prostatic carcinoma

Question 10

how does cyproterone work in cancer

Answer 10

blocks binding of dihydrotestosterone

Question 11

Cyproterone negative feedback mechanism

Answer 11

negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of luteinizing hormone resulting in diminished production of testicular testosterone