BPH

Question 1

doxazosin drug class

Answer 1

α1 specific Alpha blockers

Question 2

doxazosin target

Answer 2

Alpha adrenoceptor

Question 3

doxazosin action

Answer 3

antagonist

Question 4

doxazosin inhibits

Answer 4

Inhibits binding of normal ligand noradrenaline released from sympathetic adrenergic neurones

Question 5

doxazosin overall effect

Answer 5

Vascular smooth muscle relaxation, vasodilatation and reduction in arterial blood pressure

Question 6

doxazosin is used for

Answer 6

Hypertension
Benign prostatic hyperplasia (α1 specific)
Raynaud’s syndrome

Question 7

doxazosin important side effect

Answer 7

postural hypotension

Question 8

what does blocking release of noradrenaline at ympathetic adrenergic neurones do

Answer 8

inhibits activation of phospholipase-C enzyme leading to reduced inositol triphosphate

Question 9

what does reduced inositol triphosphate do

Answer 9

blocks the downstream phosphorylation cascade

Question 10

caution patient should take when first taking doxazosin

Answer 10

take at night as postural hypotension

Question 11

doxazosin blocks the affect of

Answer 11

catecholamines

Question 12

Tamsulosin binds to

Answer 12

selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate

Question 13

effect of tamsulosin binding to its receptors

Answer 13

relaxation of smooth muscles in the bladder neck and prostate

Question 14

dutasteride drug class

Answer 14

5-alpha-reductase inhibitors

Question 15

what does 5-alpha-reductase do

Answer 15

convert testosterone into dihydrotestosterone

Question 16

difference in finesteride and dutasteride

Answer 16

dutasteride inhibits both isomers of the enzyme

Question 17

Finasteride drug class

Answer 17

testosterone 5-alpha reductase inhibitor

Question 18

androgen responsible for the enlargement of the prostate gland

Answer 18

5 alpha-dihydrotestosterone

Question 19

which isomar converts testosterone into dihydrotestosterone

Answer 19

Type II 5a-reductase