hypo and hypernatraemia

Question 1

Vasopressin analogues

Answer 1

Desmopressin

Terlipressin

Question 2

what receptors does Desmopressin bind to

Answer 2

AVPR1, 2, 3

Question 3

actions of Desmopressin

Answer 3

Vasoconstriction
gluconeogenesis in liver
ACTH release from pituitary
water reabsorbtion collecting duct

Question 4

how is water reabsorped in the collecting duct - through what channel

Answer 4

aquaporin-2 channels

Question 5

terlipressin can be used for

Answer 5

hypotension

Question 6

terlipressin binds to what receptos

Answer 6

V1a V1b and V2

Question 7

what happens when terlipressin binds to V2

Answer 7

activates adenylate cyclase which causes the release of aquaporin 2 channels

Question 8

receptor V1a

Answer 8

which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII

Question 9

receptor V1b

Answer 9

which mediates corticotrophin secretion from the pituitary

Question 10

receptor V2

Answer 10

free water reabsorption in the renal medullar

Question 11

Tolvaptan drug class

Answer 11

Vasopressin V2 receptor antagonists

Question 12

Tolvaptan treats

Answer 12

low sodium