Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

metabolic drugs > thyroid > Flashcards

thyroid Flashcards

1
Q

thyroid replacement therapy

A

levothyroxine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

levothyroxine target

A

thyroid nuclear receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

how does levothyroxine work

A

synthetic replacement of deficient endogenous thyroid hormone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

levothyroxine possible adverse

A

hyper

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

who should you be cautious with when giving levothyroxine

A 
elderly patients
cardiovascular disease
long standing hypothyroidism
diabetes
panhypopituitarism  
predisposition to adrenal insufficiency
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

levothyroxine and thyrotoxicosis

A

don give of people have this

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

levothyroxine and diabetes

A

increase diabetic drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Beta-adrenoceptor blockers for hyperthyroidism

A

propanolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

propanolol target

A

Beta adrenoceptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

therapeutic effects are through what receptor

A

β1 receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

propanolol moa

A

Inhibits binding of noradrenaline this inhibits activation of adenylyl cyclase enzymes leading to reduced cyclic AMP. This in turn leads to reduced intracellular calcium levels.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

aim of propanolol

A

Reduce contractility (negative intropy), reduce heart rate (negative chronotropy), and BP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

propanolol common side effects

A

Dizziness; Headache, fatigue, cold hands, impotence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

where is noradrenalon released from

A

sympathetic adrenergic neurones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

propanolol severe side effects

A 
Hypotension 
Bronchoconstriction
Bradycardia and heart block 
Hypoglycaemia
Peripheral vasoconstriction including exacerbation of intermittent claudication 
Raynaud’s phenomenon
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

worry of propanolol and diabetes

A

may mask hypo symptoms

17
Q

Thionamides

A

Carbimazole

Propylthiouracil

18
Q

Thionamides

A

Carbimazole

Propylthiouracil

19
Q

Carbimazole target

A

Thyroid peroxidase enzyme

20
Q

Carbimazole moa

A

Inhibits the iodination of tyrosyl residues in thyroglobulin, inhibits coupling of iodotyrosine molecules

21
Q

Carbimazole overall effect

A

Reduces output of thyroid hormones T3 and T4 from the thyroid gland

22
Q

Carbimazole bad adverse effects

A

Agranulocytosis, neutropenia

23
Q

what is prefered to Carbimazole in pragnancy

A

propylthiouracil

24
Q

what doe thyroid peroxidase do

A

converts iodide to iodine

25
Q

Propylthiouracil binds to

A

thyroid peroxidase

26
Q

what is degraded to produce the thyroid hormones

A

Thyroglobulin

27
Q

Radioiodine (I131) is used to treat

A

hyperthyroidism and thyroid cancer

28
Q

how can Radioiodine (I131) be used for palliative

A

if the mets take up iodine

29
Q

how does Radioiodine (I131) work

A

taken up by thyroid and destroys cells by beta decay

metabolic drugs (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions