HPA Flashcards
name so glucocorticoids
Hydrocortisone
Prednisolone
Dexamethasone
Hydrocortisone drug class
glucocorticoid nuclear receptor agonist
what receptor does Hydrocortisone bind to
cortisol
what happens when Hydrocortisone binds to its receptor
translocated to the nucleus and binds to glucocorticoid response elements
what does Hydrocortisone increase
the expression of certain genes
where are binds to glucocorticoid response elements
promotor region
commonly what do glucocorticoids increase the expression of
lipocortins
what do lipocortins do
inhibit phospholipase A2, thereby reducing arachidonic acid synthesis and production of inflammatory mediators
prednisolone target
Intracellular steroid receptors
what does prednisolone mimic
action of the endogenous mediator cortisol at steroid receptors
some side effects of prednisolone that you wouldnt expect
Steroid induced cataracts
Steroid induced psychosis
what might you prescribe alongside prednisolone
bisphosphonates
Fludrocortisone drug class
mineralocorticoid
what does Fludrocortisone bind to
mineralocorticoid receptor
Fludrocortisone actions
Increase in ion and water transport
Raising extracellular fluid volume and blood pressure
Lowering potassium levels.
what would you use Fludrocortisone to treat
addisons
what is the mineralocorticoid receptor
aldosterone receptor
what is Tetracosactide
synthetic ACTH
what does Tetracosactide do
binds to ACTH receptors creating a rise in cortisol
synthetic human gowth hormone
Somatropin
Cabergoline drug class
dopamine agonist
how does dopamine from the hypothalamus act on
acts on D2 receptors on the pituitary to decrease endocrine secretion
testosterone ester
Sustanon
how is Sustanon given
IM
