HPA Flashcards

1
Q

name so glucocorticoids

A

Hydrocortisone
Prednisolone
Dexamethasone

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2
Q

Hydrocortisone drug class

A

glucocorticoid nuclear receptor agonist

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3
Q

what receptor does Hydrocortisone bind to

A

cortisol

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4
Q

what happens when Hydrocortisone binds to its receptor

A

translocated to the nucleus and binds to glucocorticoid response elements

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5
Q

what does Hydrocortisone increase

A

the expression of certain genes

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6
Q

where are binds to glucocorticoid response elements

A

promotor region

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7
Q

commonly what do glucocorticoids increase the expression of

A

lipocortins

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8
Q

what do lipocortins do

A

inhibit phospholipase A2, thereby reducing arachidonic acid synthesis and production of inflammatory mediators

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9
Q

prednisolone target

A

Intracellular steroid receptors

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10
Q

what does prednisolone mimic

A

action of the endogenous mediator cortisol at steroid receptors

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11
Q

some side effects of prednisolone that you wouldnt expect

A

Steroid induced cataracts

Steroid induced psychosis

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12
Q

what might you prescribe alongside prednisolone

A

bisphosphonates

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13
Q

Fludrocortisone drug class

A

mineralocorticoid

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14
Q

what does Fludrocortisone bind to

A

mineralocorticoid receptor

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15
Q

Fludrocortisone actions

A

Increase in ion and water transport
Raising extracellular fluid volume and blood pressure
Lowering potassium levels.

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16
Q

what would you use Fludrocortisone to treat

A

addisons

17
Q

what is the mineralocorticoid receptor

A

aldosterone receptor

18
Q

what is Tetracosactide

A

synthetic ACTH

19
Q

what does Tetracosactide do

A

binds to ACTH receptors creating a rise in cortisol

20
Q

synthetic human gowth hormone

A

Somatropin

21
Q

Cabergoline drug class

A

dopamine agonist

22
Q

how does dopamine from the hypothalamus act on

A

acts on D2 receptors on the pituitary to decrease endocrine secretion

23
Q

testosterone ester

A

Sustanon

24
Q

how is Sustanon given

A

IM

25
Q

how is testosterone produced in men

A

in leydig cells in the testes in response to LH

26
Q

where is testosterone produced in women

A

ovaries
adrenals
peripheral tissues

27
Q

what is testosterone derived from in peripheral tissues in women

A

androstenedione

28
Q

what does testosterone do in women

A

maintain libido