immunosuppressants Flashcards
azathioprine drug class
DMARD
azathioprine moa
Azathioprine is converted intracellularly to purine analogues which are incorporated into DNA and inhibit clonal expansion of B lymphocytes during the induction phase of the immune response
azathioprine risks
cancer risk of lymphoma and skin malignancies
bone marrow suppression
pancreatitis
what should you check people for before taking azathioprine
genetic polymorphisms of TPMT
what happens if 6-mercaptopurine isnt deactivated
prolonged drug life
what does TPMT do
deactivates 6-mercaptopurine
what is cyclosporin used for
graft rejection in organ and tissue transplantation
what does cyclosporin bind to
cyclophilin
cyclosporin moa
binds to cyclophilin, which causes the inhibition of calcineurin, which is responsible for activating the transcription of IL-2
main target cell of cyclosporin
T1-helper lymphocyte
Cyclophosphamide drug class
alkylating agent
what does Cyclophosphamide treat
lymphoma and leukemia
what is Cyclophosphamide converted to in the liver
aldophosphamide
what are the three ways how alkylating agents work
- Attachment of alkyl groups to DNA bases = DNA fragmentation by repair enzymes
- DNA damage via the formation of cross-links preventing DNA uncoiling for synthesis or transcription,
- mispairing of the nucleotides=mutations.
which part of the cell cycle does Cyclophosphamide work on
cell cycle-nonspecific
