erectile dysfunction

Question 1

Sildenafil drug class

Answer 1

phosphodiesterase type 5 (PDE5) inhibitor

Question 2

moa of Sildenafil

Answer 2

inhibition of PDE5 by Sildenafil slows the breakdown of the cGMP and therefore maintains the effectiveness of NO

Question 3

overall aim of Sildenafil

Answer 3

inhibition of PDE5 in the corpus cavernosum located around the penis causes smooth muscle relaxation and increased blood flow into the corpus cavernosum

Question 4

NO affect on blood vessels

Answer 4

dilation

Question 5

PDE5 action

Answer 5

breaks down cGMP

Question 6

what does cGMP do

Answer 6

encourages cells to respond to NO

Question 7

Tadalafil drug class

Answer 7

phosphodiesterase 5 (PDE5) inhibitor

Question 8

difference between Tadalafil and sildenafil

Answer 8

longer half life

Question 9

what is alprostadil

Answer 9

synthetic version of prostaglandin (PGE-1)

Question 10

alprostadil binds to

Answer 10

EP1 and EP2 receptors

Question 11

what does alprostadil binding to EP1 and EP2 receptors do

Answer 11

either an increase in cAMP and the activation of Protein Kinase A (PKA), or activation of Phospholipase C