unit 7 Flashcards
structure of herpesviridae virons
dsDNA, icosahedral enveloped capsid
members of human herpes group
HSV 1 + 2, VZV, CMV, EBV, HHV 6, 7, 8
site in which latent herpes virus infections occur
nerve cells
HSV 1 vs HSV 2 location
1: oral, ocular, CNS (above torso)
2: genital (below torso)
role of epithelial cells and sensory neurons in HSV infections
HSV1 vs HSV2 in vitro
using NAAT (PCR) test to single out gene sequence for glycoprotein 1 and 2
clinical manifestations of varicella zoster virus
chicken pox (primary infection–> rash + vesicles)
shingles (secondary infection –> rash on one side of body
clinical manifestations of CMV
congenital infections
usual specimen for detection and culture of CMV
owl’s eye (inclusion bodies)
clinical manifestations of EBV
infectious mononucleosis (mono)
clinical manifestations of EBV in children vs young adults
asymptomatic in children
triad of symptoms that are more severe (mono)
hematology findings regarding lymphocytes from individuals with active EBV infection
presence of presence of reactive lymphocytes
diagnostic use of antibodies for EBV infection
use of heterophile antibody screening test
association of EBV with Burkitt lymphoma
B cell lymphocyte cancer which increases expression and leads to increased cell proliferation
association of EBV with oral leukoplakia
EBV is apart of normal flora in mouth but can cause cancer in immunocompromised individuals
association of EBV with hodgkin lymphoma
reed-sternberg cells point towards EBV
causes of heterophile-negative infectious mononucleosis like disease
CMV, HHV6, HIV, HSV
algorithm for diagnosis of EBV infection
signs and symptoms
heamtology results that show presence of reactive lymphocytes
heterophile antibody test
EBV antibody panel
clinical significance of human herpes viruses 6,7,8
6: rosela
7:rosela
8: kaposis sarcoma
relationship between kaposi sarcoma and patients with acquired immunodeficiency syndrome
if you have Hiv or are immunocompromised, ongogenic genes of HHV8 can develop into kaposis sarcoma
clinical manifestations of adenovirus
pink eye (conjuctivitis)
clinical manifestations of hpv
warts (common, plantar, flat, perinugual
association of certain types of hpv with cervical cancer
high risk HPV types include 16, 18,31, and 45 (hpv is an oncovirus)
structure of poxviruses
large virus with inner membrane and outer envelope (dsDNA)
chickenpox vs smallpox in terms of clinical presentation
chickenpox: chest, face
smallpox: face mouth
why was the vaccination program to eliminate smallpox successful
vaccinia and its role in preventing other infections
vaccine against smallpox
pathogenesis of molluscum contagiosum
epithelial cells effected with creates wart like lesions
causative agent of erythema infectiosum
Parvovirus B19
