unit 7

Question 1

structure of herpesviridae virons

Answer 1

dsDNA, icosahedral enveloped capsid

Question 2

members of human herpes group

Answer 2

HSV 1 + 2, VZV, CMV, EBV, HHV 6, 7, 8

Question 3

site in which latent herpes virus infections occur

Answer 3

nerve cells

Question 4

HSV 1 vs HSV 2 location

Answer 4

1: oral, ocular, CNS (above torso)

2: genital (below torso)

Question 5

role of epithelial cells and sensory neurons in HSV infections

Question 6

HSV1 vs HSV2 in vitro

Answer 6

using NAAT (PCR) test to single out gene sequence for glycoprotein 1 and 2

Question 7

clinical manifestations of varicella zoster virus

Answer 7

chicken pox (primary infection–> rash + vesicles)
shingles (secondary infection –> rash on one side of body

Question 8

clinical manifestations of CMV

Answer 8

congenital infections

Question 9

usual specimen for detection and culture of CMV

Answer 9

owl’s eye (inclusion bodies)

Question 10

clinical manifestations of EBV

Answer 10

infectious mononucleosis (mono)

Question 11

clinical manifestations of EBV in children vs young adults

Answer 11

asymptomatic in children
triad of symptoms that are more severe (mono)

Question 12

hematology findings regarding lymphocytes from individuals with active EBV infection

Answer 12

presence of presence of reactive lymphocytes

Question 13

diagnostic use of antibodies for EBV infection

Answer 13

use of heterophile antibody screening test

Question 14

association of EBV with Burkitt lymphoma

Answer 14

B cell lymphocyte cancer which increases expression and leads to increased cell proliferation

Question 15

association of EBV with oral leukoplakia

Answer 15

EBV is apart of normal flora in mouth but can cause cancer in immunocompromised individuals

Question 16

association of EBV with hodgkin lymphoma

Answer 16

reed-sternberg cells point towards EBV

Question 17

causes of heterophile-negative infectious mononucleosis like disease

Answer 17

CMV, HHV6, HIV, HSV

Question 18

algorithm for diagnosis of EBV infection

Answer 18

signs and symptoms
heamtology results that show presence of reactive lymphocytes
heterophile antibody test
EBV antibody panel

Question 19

clinical significance of human herpes viruses 6,7,8

Answer 19

6: rosela
7:rosela
8: kaposis sarcoma

Question 20

relationship between kaposi sarcoma and patients with acquired immunodeficiency syndrome

Answer 20

if you have Hiv or are immunocompromised, ongogenic genes of HHV8 can develop into kaposis sarcoma

Question 21

clinical manifestations of adenovirus

Answer 21

pink eye (conjuctivitis)

Question 22

clinical manifestations of hpv

Answer 22

warts (common, plantar, flat, perinugual

Question 23

association of certain types of hpv with cervical cancer

Answer 23

high risk HPV types include 16, 18,31, and 45 (hpv is an oncovirus)

Question 24

structure of poxviruses

Answer 24

large virus with inner membrane and outer envelope (dsDNA)

Question 25

chickenpox vs smallpox in terms of clinical presentation

Answer 25

chickenpox: chest, face
smallpox: face mouth

Question 26

why was the vaccination program to eliminate smallpox successful

Question 27

vaccinia and its role in preventing other infections

Answer 27

vaccine against smallpox

Question 28

pathogenesis of molluscum contagiosum

Answer 28

epithelial cells effected with creates wart like lesions

Question 29

causative agent of erythema infectiosum

Answer 29

Parvovirus B19